Iron deposition in liver and spleen was determined qualitatively by histochemistry and quantitatively by atomic absorption spectrometry; lipid peroxidation was evaluated by the determination of thiobarbituric reactive substances. Iron deposition in liver was significantly reduced in groups supplemented with iron...
Rapid induction of iron deposition in spleen and liver with an iron-fructose chelate. The dietary effectiveness of an iron-fructose chelate was compared with FeSO4 using the criteria of total iron analyses and histologic staining technics on... C Stitt,PJ Charley,EM Butt,... - 《Proceedings of...
Western blot was used to detect iron deposition and lysosomal functions in the liver, spleen, hippocampal (HC), striatum (STR), substantia nigra (SN) and olfactory bulb (OB). Iron in serum and cerebrospinal fluid (CSF) was determined by an iron assay kit. Immunofluorescence and ...
The role of iron is supported by histologic findings of selective iron deposition in pituitary gonadotropes120 and by the reversibility of hypogonadism in primary hemochromatosis with intensive phlebotomy.121, 122 Poor pubertal growth has also been attributed to several other causes, including impaired ...
The requirement for an iron storage protein is discussed and the distribution and role of ferritin in iron metabolism are reviewed. The structure of the protein shell and of the iron contained within it is described and the molecular mechanisms which may be involved in ferritin iron deposition and...
(due to inflammation) despite elevated serum ferritin, high ferritin deposition in the liver and high intracellular iron sequestration in cells leads to anemia of inflammation in COVID-19 patients. Elevated serum hepcidin is the main reason for this. Moreover, in anemia of inflammation, there is...
In order to understand the splenic toxicity of aniline in rats, early interaction of aniline with erythrocytes and its subsequent deposition and covalent binding to macromolecules in target (spleen) and nontarget (liver) organs have been studied. Male Sprague-Dawley (SD) rats were given 1 or 3...
Although iron deficiency occurred commonly in the elderly, accumulation of iron in certain organs and tissues was observed, including brain, liver, spleen, kidney, and skeletal muscles, indicating malfunction of iron homeostasis [5, 22]. Iron deposition in senescent cells was observed, which was ...
Therefore, serum ferritin and TSAT remain the values considered for iron overload, as noted in the study by Ghoti et al. where hemodialysis patients with ferritin >1000 ng/dL, who had increased iron deposition in the liver and spleen, were studied.9 Therefore, in our study, a cut-off ...
20, 21 Disruption of the HAMP/FPN axis, in a manner that reduces HAMP levels or FPN responsiveness to HAMP, leads to the iron-overload disease hemochromatosis. This is characterized by increased serum iron concentration, depletion of iron from the spleen, and excess deposition in the liver.22...