Liver diseaseFerroptosisFerritinophagyFerroptosis modulatorsIt was clearly realized more than 50 years ago that iron deposition in the liver may be a critical factor in the development and progression of liver disease.The recent clarification of ferroptosis as a specific form of regulated hepatocyte ...
Iron deposition in the liver and guts of giant South American freshwater turtle Podocnemis expansa (Schweigger 1812) from a commercial breeding farm in Acr... A Conrado,AD Oliveira,L Medeiros,... - 《Multidisciplinary Science Journal》 被引量: 0发表: 2022年 Avaliação da cavidade oro...
Differences in liver iron levels were confirmed by Perl's staining in liver sections, which demonstrated that male mice have very little iron deposition in the liver regardless of dietary iron levels (Fig. 3g), whereas female Ndfip2−/− mice on a normal diet show increased liver iron ...
the plasma latent iron-binding capacity is normal, iron binds to transferrin prior to reaching the liver; when the plasma latent iron-binding capacity is low, a portion of the iron reaches the liver either unbound or abnormally bound to transferrin, resulting in its immediate hepatic ...
Although neonatal hemochromatosis (NH) is a well-known cause of liver failure during the neonatal period and iron deposition in extrahepatic tissues is considered essential in the diagnosis of NH, there is no consensus regarding the pathology or diagnostic criteria of NH. Recent studies of immunohist...
Alcohol-induced increase in hepatic transferrin receptor-1 expression and up-regulation of high iron protein in Kupffer cells (proposed) facilitate iron deposition and retention in the liver. Iron is loaded in both parenchymal and nonparenchymal liver cells. Iron-loaded liver can promote ferroptosis ...
Introduction The purpose of this study is to detect the role of breath-hold multiecho T2∗-weighted MRI, in quantification of hepatic iron deposition in patients with sickle cell disease. Methods Thirty-seven patients underwent 1.5-T MRI of the liver that included a multiecho T2∗-weighted ...
In the present study, we have investigated whether ANG II can also induce iron accumulation in the liver. Prussian blue staining detected frequent iron deposition in the interstitium of the liver of rats treated with pressor dose ANG II for 7 days, whereas iron deposition was absent in the ...
He was referred for combined heart and liver transplantation. Cardiac iron deposition can be diagnosed readily using right ventricular biopsy or T2* magnetic resonance imaging. Early detection may allow time for intensive chelation therapy, which might, in turn, reverse the myopathic process. Improved...
(Perls) staining (Figure 11.36c). It is not possible to histologically distinguish primary from secondaryiron overload. CMR-derived T2* relaxation time is currently the mainstay for thequantitative assessmentof cardiac iron deposition and is a useful technique to follow response to iron-chelation ...