IRF-4 is a transcription factor belonging to the interferon regulatory factor family, primarily expressed in lymphoid cells. It plays a crucial role in the regulation of gene expression in B cells, particularly in enhancing the expression of Ig light chain genes upon B cell activation. ...
Using an inhibitor screen, we identified nuclear factor κB (NF-κB) as a candidate regulator of IRF4 expression and cell proliferation. We then demonstrated that the NF-κB subunits p52 and RelB were transcriptional activators of IRF4. Further analysis showed that activation of CD30 promotes ...
Trypsin inhibitor 胰蛋白酶抑制剂 CAS:9035-81-8 在线交易 48小时发货 少货必赔 破损包赔 百克赛斯生物科技(镇江)有限公司 2年 查看详情 面议 上海 Aloxistatin 蛋白酶抑制剂纯度高质检保证仅供科研 上海陶术生物科技有限公司 4年 查看详情 ￥780.00/盒 上海 人半胱氨酸蛋白酶抑制剂/胱抑素C(Cys-C)ELISA...
Cells were lysed in Tris-HCl, pH 6.8, with 2% Igepal CA630, 2% SDS, 10 mm sodium β-glycerophosphate, 10 mm sodium fluoride, 2.5 mm sodium pyrophosphate, 1 mm sodium orthovanadate, and EDTA-free protease inhibitor mixture (Roche Applied Science/Sigma). Lysates were sonicated on ice for 20...
Thus, exogenous IRF4 administration, like MDP administration, is an effective inhibitor of TNBS colitis. In further studies, we investigated the interaction between the exogenously administered FLAG-tagged IRF4 and RICK, TRAF6, and MyD88 in the colonic mucosa of the mice subjected to intrarectal ...
suggesting that the anti-neuroinflammatory effect of ABBV-744 might be associated with regulation of BATF2-IRF4-STAT1/3/5 pathway, which was confirmed by gene knockdown experiments. This study demonstrates the effect of a BD2 high selective BET inhibitor, ABBV-744, against microglial inflammation,...
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K-AKT pa...
inhibitor NC对细胞行为学没有显著影响;黄芩素+miR-125b-5p inhibitor组细胞克隆,侵袭,凋亡则介于黄芩素组与miR-125b-5p inhibitor组之间.结论:黄芩素能抑制AMC-HN-8细胞增殖,其机制可能与miR-125b-5p靶向抑制IRF4的表达,诱导促凋亡蛋白Bax,cleaved-caspase-3,Cyto-c,抑制凋亡抑制蛋白Bcl-2从而诱导细胞凋亡有...
In this study, we evaluated the therapeutic effects of ABBV-744, a BD2 high selective BET inhibitor, on lipopolysaccharide (LPS)-induced microglial inflammation in vitro and in vivo, and explored the key pathways by which ABBV-744 regulated microglia-mediated neuroinflammation. We found that ...
Knockdown of p65 by shRNA also significantly inhibited cellular growth of multiple ATL/HTLV-1-transformed T-cell lines (supplemental Figure 2B-C), supporting previous research with a small-molecule IKK inhibitor.20 These results suggested that IRF4 and NF-κB are key transcription factors in ATL...