IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastomaGlioblastomaRRV-mediated gene therapyIRF8MDSCImmunosuppressionBACKGROUND. Glioblastoma (GBM) has a highly immunosuppressive tumor immune microenvironment (TIME), largely...
Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expressio...
Here, we investigated that IRF-1 regulates C-X-C motif chemokine 10 (CXCL10) and chemokine receptor 3 (CXCR3) to activate anti-tumor immunity in HCC. We found that IRF-1 mRNA expression was positively correlated with CXCL10 and CXCR3 through qRT-PCR assay in HCC tumors and in analysis...
Thus, IRF2 regulates a multi-directional response that instills exhaustion while also suppressing the expression of multiple transcriptional nodes that sustain effector function in times of chronic antigen stimulation. Resistance to checkpoint inhibitors and adoptive cell therapies remains a significant ...
IMCs suppress T cell function and dampen the anti-tumor response. In this study, we sought to "reprogram" IMCs into antigen-presenting cells (APCs) to enhance anti-tumor T cell responses. To induce IMC differentiation into APCs, we utilized a retroviral replicating vector (RRV) expressing IRF...