We present in this work a set of accurate instrument response functions of DAMPE (DmpIRFs) including the effective area, point-spread function and energy dispersion that are crucial for the gamma-ray data analysis based on the high statistics simulation data. A dedicated software named DmpST is...
pyirfis a python library for the generation of Instrument Response Functions (IRFs) and sensitivities for theCherenkov Telescope Array (CTA). Thanks to its simple input/output and modular function-based structure, it can be used to process also data from other Imaging Atmospheric Cherenkov Telescop...
Thus, we hypothesized that IRF8 modulates leukocyte recruitment, differentiation, and function during the early stages of IRI-induced AKI. 2. Materials and methods 2.1. Design of the human study This study included three distinct patient cohorts. 1) The first cohort comprised 15 patients with AKI...
Logic of the criteria : The rotation rate of the Radec frame in AltAz is a function of the observatory latitude, and pointing in altaz. Using this first order derivative, a given limit on rotation can be converted in a maximum observation time. It should be valid as long as the rotation...
IRF4-C99R shows loss-of-function at ISRE but is functionally active To characterize IRF4-C99R, we first explored its DNA-binding activity to the Interferon-Stimulated Response Element (ISRE) containing three consensus motifs 5′-GAAA-3′ (Fig. 1b and Supplementary Fig. 1f), one of the ...
(Treg), Th2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been ...
Therefore, our data demonstrate a novel role for IRF5 in regulating airway function via enhanced type 2 skewing (Figure 1), in addition to mucus and collagen production in response to HDM (Figure 2). IRF5 deficiency impairs pulmonary homeostasis via increased ECM deposition and IL-13 production...
Interferon regulatory factor 8 (IRF8) is a transcription factor that controls the development and function of mammalian myeloid hematopoietic cells [1,2,3,4,5,6], but also their function, including their response to interferon gamma (IFN-γ) [1, 7]. Autosomal recessive (AR) complete IRF8 ...
To further verify the essential function of IRF8 and the on-target effect of our sgRNAs, we ectopically expressed CRISPR-resistant IRF8 cDNA in leukemia cells (Figures 1C–1F). To enable rapid perturbation of IRF8 in AML, we fused the CRISPR-resistant IRF8 cDNA with an FKBP12G36V domain...
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