Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults[J]. Blood, 2011,118(1):139-147. DOI: 10.1182/blood-2011-01-330795 . 返回引文位置Google Scholar 百度学术 万方数据 [2] Swerdlow SH , Campo E , ...
In this study, we identified that the transcription factor IRF4 integrates signals to coordinate the NK cell response during mouse cytomegalovirus infection. Loss of IRF4 was detrimental to the expansion and differentiation of virus-specific NK cells. This defect was partially attributed to the inabil...
Pediatric large B-cell lymphomas (LBCLs) share morphological and phenotypic features with adult types but have better prognosis. The higher frequency of some subtypes such as LBCL withIRF4rearrangement (LBCL-IRF4) in ch...
IRF4 inhibition by lenalidomide reduced CARD11-BCL-10-MALT1 complex activity of ABC-DLBCL cells (as measured by BCL-10 cleavage) and resulted in downregulation of B-cell receptor (BCR)-dependent NF-κB activity. An NF-κB-driven luciferase assay revealed that lenalidomide (1 μM) inhibited ...
摘要：干扰素调节因子４（ＩＲＦ４）在多种免疫细胞中表达并参与调节多种免疫反应㊂ＩＲＦ４与机体多种慢性炎性疾病以及呼吸道过敏性疾病相关，抑制ＩＲＦ４的表达或功能，可以达到减轻或延缓疾病发生发展的作用㊂研究ＩＲＦ４在慢性鼻病和气道过敏性疾病中的作用与机制有助于为疾病治疗提供新思路㊂ 关键词：...
IRF4 participates in the process of antivirus, Th cell differentiation and B cell maturation by regulating the expression of IFN and some lymphokines. In this study, Cherry Valley duck IRF4 ( duIRF4) was cloned and its cDNA was analyzed. Expression of duIRF4 in a wide variety of tissues...
IRF-4 drives expression of Zbtb20 in B1 cells and plasma cells by directly binding to its promoter. Zbtb20 is dispensable for B cell development, initial GC responses and generation of affinity-matured plasma cells. However, Zbtb20-deficiency resulted in a profound defect in long-term antibody...
IRF4 not only plays important roles in the activation of both B- and T-lymphoid cells, but is also required for the generation of germinal center (GC) B cells and orchestrates terminal B-cell differentiation, i.e., the formation of plasma cells17,18,19. Apart from these functions during...
摘要: IRF4 regulates GC B cell differentiation by directly activating Bcl6 and Obf1IRF4 cellular concentrations orchestrate antigen-induced B cell fatesOccupancy of ISRE motif correlates with high cellular concentrations of IRF4ISRE motifs are enriched in plasma cell genes关键词:...
The Study on the Relation ofIRF4Expression and Prognostic Value in Patients with Diffuse Large B-cell Lymphoma; 转录因子IRF4在弥漫性大B细胞淋巴瘤中的表达及与其预后关系的研究 2) IR IR 1. Syntheses of IrO_x-TiO_2 Nano-powers from TiN via Impregnation-thermal Decomposition Method and Its Chara...