此外,IRF4/MUM1的表达不受干扰素的影响,而是由与淋巴细胞活化有关的刺激物介导的,如刀豆素A、金黄色葡萄球菌肠毒素A、白细胞介素4(IL-4)、抗原受体、脂多糖类及CD40信号等[4]。 2 IRF4在淋巴细胞发育中的作用 IRF4/MUM1主要在淋巴细胞中表达,有种系和阶段...
第二部分抑制IL-4/STAT6/IRF4信号通路降低嗜酸性慢性鼻窦炎伴鼻息肉的上皮-间质转化影响目的:先前研究表明,鼻黏膜上皮细胞的上皮-间质转化(epithelial-to-mesenchymal transition,EMT)对慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSw NP)的组织重塑至关重要.然而,人们对EMT发生的确切机制尚不...
大鼠白介素4(IL-4)ELISA试剂盒 Rat Interleukin 4,IL-4 ELISA试剂盒 大鼠白介素2(IL-2)ELISA试剂盒 Rat Interleukin 2,IL-2 ELISA试剂盒 大鼠白介素1α(IL-1α)ELISA试剂盒 Rat Interleukin 1α ,IL-1α ELISA试剂盒 大鼠白介素18(IL-18)ELISA试剂盒 Rat Interleukin 18,IL-18 ELISA试剂盒 大鼠白...
First, after an initial response to interleukin-4 (IL-4), cells that were committed to an ASC fate downregulated the CD23 marker and IL-4 signaling, whereas cells that maintained IL-4 signaling did not differentiate. Second, human CD23(-) cells also increased IRF4 protein to levels ...
摘要：干扰素调节因子４（ＩＲＦ４）在多种免疫细胞中表达并参与调节多种免疫反应㊂ＩＲＦ４与机体多种慢性炎性疾病以及呼吸道过敏性疾病相关，抑制ＩＲＦ４的表达或功能，可以达到减轻或延缓疾病发生发展的作用㊂研究ＩＲＦ４在慢性鼻病和气道过敏性疾病中的作用与机制有助于为疾病治疗提供新思路㊂ 关键词：...
在MM中,骨髓微环境来源的促炎因子和抗病毒干扰素信号在疾病的进展中起关键作用。这些驱动因素包括IL6以及IRF和STAT依赖的信号。有证据支持异常激活B细胞祖细胞关键存活因子IRF4对发病和进展是必需的。但是IRF信号对维持祖细胞的作用尚不清楚...
klB980Mu 小鼠白介素33(IL33)ELISA试剂盒现货供应 ELISA Kit for Interleukin 33 (IL33) klB154Mu 小鼠纤维蛋白原α(FGα)ELISA试剂盒现货供应 ELISA Kit for Fibrinogen Alpha (FGa) klB897Mu 小鼠胰岛素降解酶(IDE)ELISA试剂盒现货供应 ELISA Kit for Insulin Degrading Enzyme (IDE) ...
最后,进一步探索了IRF4K123位点单甲基化修饰调节Th2细胞转录因子GATA3的分子机制.发现IRF4K123位点的单甲基化加强其与STAT6的结合,并介导IRF4,STAT6和TIP60的相互作用.染色体免疫共沉淀发现SUV39H1介导的IRF4单甲基化通过不同途径调控Th2细胞相关下游基因的表达:1)IRF4K123位点的单甲基化直接调节其自身在IL-4基因...
(Th)2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been demonstrated to ...
Th9 cells produce interleukin (IL)-9, a cytokine implicated in allergic asthma and autoimmunity. Here we show that Itk, a mediator of T cell receptor signalling required for Th2 immune responses and the development of asthma, is a positive regulator of Th9 differentiation. In a model of ...