活化的 STING 可迁移并激活 TBK1,诱导 IRF3 和 NF-κB 的磷酸化,从而触发促炎细胞因子的转录。与此相一致,scRNA-seq 数据也显示转录因子 Nfkb1 和 Irf3 的调节子活性在 Gsdmd-/-ApoE-/- 小鼠中降低,这些降低主要发生在 M1 巨噬细胞中。因此,作者推测 GSDMD 在氧化-LDL 诱导的 MPMs 中通过线粒体穿孔调节...
for mammalian host defense involved in innate immune signaling.The cytoplasmic region of TLR is the toll/interleukin receptor(TIR) domain responsible for the recruitment of TIR domain bearing adaptors including Mal,MyD88,TRIF and TRAM bifurcating for NF-kB and IRF activation.Little is known about ...
(IRAK) complex resulting in phosphorylation of IKKa/b, activation of the transcription factors NFkB, AP1,IRF1, andIRF7, and generation of the pro-inflammatory cytokines IL-6 and TNFα, among others. TLR3, on the other hand, signals through the MyD88 independent pathway, initiated by the...
BY-PP41754 猪瘟病毒IgG抗体(CSFV-IgG)elisa试剂盒BY-PP42232 猪核转录因子p50(NF-KB p50)elisa试剂盒 BY-PP42704 猪载脂蛋白C3(apo-C3)elisa试剂盒BY-PP42270 猪维生素D25羟化酶(CYP2R1)elisa试剂盒 BY-PP41888 猪胃抑素(GIP)elisa试剂盒BY-PP42801 猪维生素D(VD)elisa试剂盒 BY-PP42504 猪(CP-...
Bakhoum SF.等发现肿瘤细胞的基因组不稳定性导致STING信号感应细胞溶质DNA从而被激活,STING信号的活化激活下游非经典NF-kB信号通路,从而促进癌细胞的转移[15]。最近的一项研究报道,cGAS过表达增强了双链DNA损伤并导致肺癌模型中的基因组不稳定,并诱导恶性转化,刺激体外增殖并加速肺癌细胞体内肿瘤生长[16]。另外,据报道...
Acetyl-NF-kB p65 (Lys310) Antibody 100uL LKB1 (D60C5) Rabbit mAb 100uL PDK1 Antibody 100uL Phospho-Met (Tyr1234/1235) (D26) XP Rabbit mAb 40ul IRS-2 (L1326) Antibody 100uL Smad2/3 Antibody 100uL Phospho-Met (Tyr1234/1235) Antibody 100uL Met (25H2) Mouse mAb 300uL ...
Northern blot analysis detected a 1.6-kb constitutively expressed IRF3 transcript. The deduced 427-amino acid IRF3 protein is 34 to 40% identical to other members of the IRF family in the N-terminal region. Au et al. (1995) showed that IRF3 is a 50-kD protein....
Anti-NFkB p100/p52 antibody细胞核因子/k基因结合核因子 p52/p100抗体一抗 Anti-Phospho-PDGF Receptor beta (Tyr751) antibody磷酸化血小板源性生长因子受体-B抗体一抗 Anti-PKC gamma antibody蛋白激酶C亚型G抗体一抗 Anti-Phospho-PFKFB3/PFK2 (Ser467) antibody磷酸化果糖-2,6-二磷酸酶3/磷酸果糖激酶2抗体...
Collectively, these results show that MAVS is a potent activator of IRF3, IRF7, and NF-κB and that its overexpression is sufficient to mimic viral infection to induce cytokines including IFN-α, IFN-β, and RANTES. Download: Download high-res image (550KB) Download: Download full-size ...
偶联FITCNFKB1 抗体:偶联HRPNFKB1 抗体:偶联PE/ATTO 594NFKB1 抗体:偶联PerCPNFKB1 抗体:偶联RPENFKB1 抗体:偶联StreptavidinOCT4 抗体OCT4 抗体:偶联ATTO 390OCT4 抗体:偶联ATTO 488OCT4 抗体:偶联ATTO 565OCT4 抗体:偶联ATTO 594OCT4 抗体:偶联ATTO 633OCT4 抗体:偶联ATTO 655OCT4 抗体:偶联ATTO 680...