Interleukin‐2 (IL‐2) (production of T cells in vitro ) and blood histamine values, before and after Tranilast therapy, were measured, and the following results were obtained: 1) Compared with healthy controls, the IL‐2 producing ability of T cells in patients with AD was increased. 2)...
MH Kaplan, YL Sun, T Hoey, MJ Grusby Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature, 382 (1996), pp. 174-177 View in ScopusGoogle Scholar 18 DJ Slivnick, TM Ellis, JF Nawrocki, RI Fisher The impact of Hodgkin's disease on the immu...
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. B cells cultured with anti-IgM, BSF-p1, and B15-TRF will differentiate into high rate IgM-synthesizing cells in the presence of supernatants from EL-4 cell.....
Acute rejection of murine bone marrow allografts by natural killer cells and T cells: Differences in kinetics and target antigen recognized J Exp Med, 166 (1987), p. 1499 View in ScopusGoogle Scholar 4. Clerigue M, Pisa P, Tsai L, Hanson M Effects of interleukin-2 and interleukin-2 acti...
,Holbrook,and,Douglas,C.摘要: The levels of interleukin 2 (IL-2), interleukin 2 receptor (IL-2R), and interferon-γ (IFN-γ) specific mRNA and their gene products were examined in phorbol myristate acetate (PMA) and calcium ionophore A23187-costimulated purified T cells from young and ...
by cells that express the IL-2 receptor subunit CD25 (also known as IL-2Rα), notably regulatory T (TReg) cells. During an immune response, activated antigen-specific CD4+and CD8+T cells produce large amounts of IL-2, which is then consumed by CD25+effector T cells and TRegcells. ...
The dominant role of interleukin-2 (IL-2) is in the maintenance of regulatory T cells rather than of effector T cells. This has led to clinical interest in the use of low-dose IL-2 to control autoimmune and inflammatory disorders, with promising initial
cells. The primary function of IL-2 is to promote the proliferation of both CD8+ T and CD4+ cells. It has been shown that there is a contribution from IL-2 to the T cells’ regulatory development. In a consequence, the use of IL-2 could stimulate the immune system therapeutically.[5...
Activation of nave T cells requires synergistic signals produced by the T-cell receptor (TCR) and by CD28. We previously identified the novel adaptor ALX, which, upon overexpression in Jurkat T cells, inhibited activation of the interleukin-2 (IL-2) promoter by TCR/CD28, suggesting that it ...
Interleukin 1 (IL-1) production by freshly isolated and lipopolysaccharide (LPS)-stimulated adherent monocytes-macrophages and IL-2 production by unstimulated and phytohemagglutinin (PHA)-activated T cells were examined in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex ...