The biology of interleukin-2. (ekt)Malek, Thomas R
Wang, X., Rickert, M. & Garcia, K. C. Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors.Science310, 1159–1163 (2005). ArticleCASPubMedGoogle Scholar Waldmann, T. A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy...
To make further investigation, we analyzed the profile of cytokines in plasma of patients with COVID-19 pneumonia using luminex. The level of interleukin-2 (IL-2) in critical patients was significantly lower than that in severe patients, whereas the level of IL-2 in severe patients was higher...
FUNCTIONAL interleukin-2 receptors (IL-2Rs) onlymphoid cellsconsist of at least three distinctmembrane proteins: IL-2Rα (p55), IL-2Rβ (p70-p75), and IL-2Rγ (p64).1The a subunit can bind IL-2 with low affinity, but lacks the ability to transduce intracellular signals mediated by ...
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4 来自 bloodjournal.org 喜欢 0 阅读量: 16 作者:KS Wang,DA Frank,J Ritz 展开 摘要: The STAT binding oligonucleotide used, 5Ј-GAGCCTGATTTCCCC- GAAA...
Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted therapeutic strategies. However, the dynamic...
no association was observed with CMV infection or reactivation in patients. KIR+T cells express the common β chain of the interleukin 2 and interleukin 15 receptors. In addition, IL-15 and its receptor play an important role in generation and maintenance of memory CD8+T cells32. As IL-15 ...
The first symposium in this series was held at the Royal College of Surgeons of England in December 1988 and was entitled "Novel Neutrophil Stimulating Peptides". That symposium successfully brought together the majority of laboratories working in the area of interleukin-8 and related peptides; see...
In murine peripheral blood, iNKT cells constitute ~0.5% of mononuclear cells3. To facilitate research on murine iNKT cells, hybridoma cell lines were successfully generated and have proven invaluable tools to study the biology of iNKT cells4,5,6,7. In human iNKT cells, the invariant Vα24-J...
2. The protein of claim 1 which has a molecular weight of approximately 41,000 daltons. 3. The protein of claim 1, which is characterized by the ability to regulate the level of gene expression controlled by a promoter of the interleukin-2 receptor alpha chain gene. ...