1991. Interferon- inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J. Biol. Chem. 266:21404 -21408.Nakayama M, Nagata K, Kato A, Ishihama A. Interferon- inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J Biol Chem 1991; ...
Their repertoire has recently been expanded to the regulation of inflammasome complexes, which are cytosolic multi-protein complexes that control an inflammatory cell death called pyroptosis and the release of cytokines like interleukin-1尾 and interleukin-18. Here we discuss recent advances in ...
immunity-related GTPase; ISG15, IFN-stimulated gene 15 kDa protein; MX1, myxovirus resistance 1; NOS2, nitric oxide synthase 2; NRAMP1, natural resistance-associated macrophage protein 1; OAS, 2ʹ-5ʹ oligoadenylate synthase; PKR, IFN-induced, RNA-activated protein kinase.*Other NADPH...
have no homologs in the pufferfishes, with their single tandem pair of irg proteins, and recalls the recent observation that the gap protein of the small gtpase, rap1, is itself probably derived from a gtpase ancestor, retaining the g-domain structure but not the sequence to reveal its ...
E. Prenylation of an interferon-γ-induced GTP-binding protein: the human guanylate binding protein, huGBP1. J. Leukoc. Biol. 60, 423–431 (1996). Article CAS PubMed Google Scholar Traver, M. K. et al. Immunity-related GTPase M (Irgm) proteins influence the localization of guanylate-...
The murine Mx1 protein is an interferon-inducible nuclear protein and confers resistance to influenza virus infection even though the resistance mechanism is yet unclear. The Mx1 protein contains a tripartite GTP-binding domain consisting of GXXXXGKS, DXXG, and T/NKXD motifs. In the GTPase gene...
The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen Article Open access 25 August 2020 References Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, et al. Immunity-related GTPase M (IRGM) proteins inf...
Loss of the interferon-g-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activa- tion of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic suscepti- bility of Irgm1-deficient mice to infection. BMC Biology 2016; 14:1-20; PMID:26728391...
Interestingly, the extracellular‐signal‐regulated kinase 1/2 mitogen‐activated protein (MAP) kinases and signal transducer and activator of transcription 1 (STAT1) transcription factor levels were considerably induced in knockdown cells compared to the control cells. However, no change in the level ...
This revealed that a 78-kDa interferon-inducible GTPase, MxA, was expressed in PC-3 but not in PC-3M cells. The gene encoding MxA, MX1, is located in the region of chromosome 21 deleted as a consequence of fusion of TMPRSS2 and ERG, which has been associated with aggressive, invasive...