A giant GTPase, very large inducible GTPase-1, is inducible by IFNs The complex, partially overlapping, cellular responses to IFN type I (IFN-alpha and -beta) and IFN type II (IFN-gamma) involve several hundred genes that c... T Klamp,U Boehm,D Schenk,... - 《Journal of Immunology...
1991. Interferon- inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J. Biol. Chem. 266:21404 -21408.Nakayama M, Nagata K, Kato A, Ishihama A. Interferon- inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J Biol Chem 1991; ...
The murine Mx1 protein is an interferon-inducible nuclear protein and confers resistance to influenza virus infection even though the resistance mechanism is yet unclear. The Mx1 protein contains a tripartite GTP-binding domain consisting of GXXXXGKS, DXXG, and T/NKXD motifs. In the GTPase gene...
应用类型 ELISA, WB 免疫原 Immunity-Related Gtpase Family, Cinema 来源宿主 兔 反应性 人,小鼠,大鼠 保存建议 建议收到该Interferon-Inducible GTPase 5 (IRGC) Antibody产品后,储存温度为-20°C。避免重复冻融 其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命...
H. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61, 1063–1074 (1990). Article CAS PubMed Google Scholar Yarar, D., Waterman-Storer, C. M. & Schmid, S. L. A dynamic actin cytoskeleton functions...
Among 20 IRG proteins in mice, GM4951 displays the highest sequence identity (77%) with interferon inducible GTPase 1 (IIGP1, now known as IRGA6) (Supplementary Fig.5a). The crystal structure of IRGA6 revealed that GTP-dependent oligomerization of IRGA6 is required for cooperative GTP hydroly...
Interferon-inducible effector mechanisms in cell-autonomous immunity 2012, Nature Reviews Immunology View all citing articles on Scopus 2 The abbreviations used are: IRG immunity-related GTPase GBP guanylate-binding protein TUBE 1 tandem ubiquitin binding entity 1 MEF mouse embryonic fibroblast GMS glycine...
Our previous studies using differential mRNA display have shown that interferon-纬-inducible GTPase (IGTP), was up-regulated in coxsackievirus B3 (CVB3)-infected mouse hearts. In order to explore the effect of IGTP expression on CVB3-induced pathogenesis, we have established a doxycycline-inducible...
Loss of the interferon-g-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activa- tion of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic suscepti- bility of Irgm1-deficient mice to infection. BMC Biology 2016; 14:1-20; PMID:26728391...
Interferon‐γ‐inducible GTPase (IGTP) expression is upregulated in coxsackievirus B3 (CVB3)‐infected murine heart and inhibits CVB3‐induced apoptosis through activation of the PI3 kinase/Akt pathway. However, the mechanism of this pathway activation is unknown. In this study, using doxcycycline...