The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem 2002; 277: 6080.Gorbacheva VY, Lindner D, Sen GC, Vestal DJ. The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol...
Macrophage activation by interferon (IFN)-gamma is characterized by enhanced phagocytosis and killing of internalized pathogens. We studied the effects of IFN-gamma on Rab5a, a GTPase involved in both endocytosis and phagocytosis. IFN-gamma induced the synthesis of Rab5a in mononuclear cells as dete...
Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4. T, Nakajima K, Tachibana T, Hirano T, Yoneda Y: Interferon- gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4. ... T Sekimoto,K Nakajima,T Tachibana,......
On the other hand, TRIMs are induced in macrophages and myeloid DCs and function to limit viral entry, most notably that of retroviruses [28]. IFN-γ-inducible proteins can also employ components of the autophagic machinery to curb viral replication. For example, IFN-inducible GTPases utilize ...
60.Rapid interferon-gamma release from natural killer cells induced by a streptococcal commensal 机译:链球菌共刺激诱导的自然杀伤细胞中γ-干扰素的快速释放 作者:BouwerA.L.;SaundersonS.C.;DunnA.C.;LesterK.L.;CrowleyL.R.;JackR.W.;McLellanA.D. 期刊名称:《Journal of interferon and cytokine rese...
et al. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J. Immunol. 182, 3775–3781 (2009). 97. Halonen, S. K., Taylor, G. A. & Weiss, L. M. Gamma interferon-induced inhibition of Toxoplasma gondii in ...
Interferons(IFNs) can induce the expression of IFN-stimulated genes (ISGs), such asmyxovirusresistance (Mx) protein, to inhibit virus replication. In this study, the expression of Mx gene in mandarin fish, and the IFN-sensitiveresponse elements(ISREs) and gamma-interferon activated sites (GASs...
Cells that lacked GABARAPs but not LC3 proteins and mice that lacked Gate-16 alone were defective in the IFN-γ-induced clearance of vacuolar pathogens such as Toxoplasma. Gate-16 but not LC3b specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform ...
Mouse guanylate-binding protein 3 (mGBP3) is a 71-kDa GTPase which belongs to GTP-binding protein family. The present study showed that the expression of mGBP3 transcript was readily induced in a dose dependent fashion in the macrophage cell line RAW264.7 treated with either interferon-gamma (...
the gtpase-activating protein rap1gap uses a catalytic asparagine. nature. 2004, 429: 197-201. 10.1038/nature02505. article pubmed google scholar gilly m, wall r: the irg-47 gene is ifn-gamma induced in b cells and encodes a protein with gtp-binding motifs. j immunol. 1992, 148: 3275...