Fagan, Richard JosephChvatchko, YolandeGutteridge, AlexPower, ChristineBoschert, UrsulaPhelps, Christopher Benjamin
Interferon-gamma Interferon-γ (ΙFNγ), which is the only type-II interferon, is produced in large amounts by Th1 and Tc1 cells early after HSCT and is the classical “Th1” cytokine generated duringGVHD. IFNγ plays a pathogenic role in gastrointestinal GVHD, but, interestingly, has a ...
Interferons (IFNs) are a family of naturally occurring proteins, produced by eukaryotic cells in response toviral infectionand other biologic agents. Three major types of interferons have been defined: type I (IFN-alpha, beta, epsilon, kappa and omega), type II (IFN–gamma) and type II...
abundantneutrophilinfiltrates in perivascular derma resulting in chronic dermatitis ranging from nodular to pernio-like lesions.Periodic feverepisodes,failure to thrive,hepatosplenomegaly, abdominal protrusion due to intra-abdominalfat deposition,panniculitis,basal gangliacalcifications, anemia,hypergammaglobulinemia...
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. In these studies, IFN[gamma]-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in BALB/c or C57BL/6 mice, but like IL-1[alpha], potentiat....
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer 尝试做个小精读 CTL:cytotoxic T lymphocytes 细胞毒性T淋巴细胞 KP小鼠:Kras G12D / Trp53双敲肺癌细胞系接种小鼠 ...
For the in vitro experiment, the pituitary tissues were supplemented with IFN-γ, and the mRNA expression levels of follicle-stimulating hormone beta subunit (FSH-β), interferon gamma receptor 1 (IFNGR1), and interferon gamma receptor 2 (IFNGR2) in the pituitary were assessed. Results Monocyte...
237 shared DEGs) induced byC. aurisandC. albicans(those 1096 genes found across all studies: Suppl. TableS11). (e), Dotplot of enriched signaling pathways by the 237 shared DEGs.DEGs, differentially expressed genes; IFN, interferon; ORA, overrepresentation analysis; TLR, Toll-like receptor. ...
Don't use ACTIMMUNE if you are allergic to interferon-gamma,E. coliderived products, or any ingredients contained in the product. What warnings should I know about ACTIMMUNE? At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions. ...
(i) said polypeptide is a Type II interferon or a Type II interferon-like molecule; (ii) said nucleic acid molecule comprises a sequence of nucleotides which is at least 40% identical to the nucleotide sequence set forth in SEQ ID NO:1; and ...