INTERFERON GAMMA - LIKE PROTEINThis invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of...
Interferon-gamma Interferon-γ (ΙFNγ), which is the only type-II interferon, is produced in large amounts by Th1 and Tc1 cells early after HSCT and is the classical “Th1” cytokine generated duringGVHD. IFNγ plays a pathogenic role in gastrointestinal GVHD, but, interestingly, has a ...
Theinterferonsare a family ofglycoproteinsthat include interferon-alpha (from leukocytes), --beta (from fibroblasts), and -gamma (from T lymphocytes). Interferon was the first cytokine to show activity in patients withmetastatic RCC. All three interferons cause a flu-like syndrome whosehemodynamicbur...
Don't use ACTIMMUNE if you are allergic to interferon-gamma,E. coliderived products, or any ingredients contained in the product. What warnings should I know about ACTIMMUNE? At high doses, ACTIMMUNE can cause (flu-like) symptoms, which may worsen some pre-existing heart conditions. ...
Interferons (IFNs) are a family of naturally occurring proteins, produced by eukaryotic cells in response toviral infectionand other biologic agents. Three major types of interferons have been defined: type I (IFN-alpha, beta, epsilon, kappa and omega), type II (IFN–gamma) and type II...
Monitor renal function regularly when administering ACTIMMUNE in patients with severe renal insufficiency; accumulation of interferon gamma-1b may occur with repeated administration. Renal toxicity has been reported in patients receiving ACTIMMUNE USE IN SPECIFIC POPULATIONS ...
For the in vitro experiment, the pituitary tissues were supplemented with IFN-γ, and the mRNA expression levels of follicle-stimulating hormone beta subunit (FSH-β), interferon gamma receptor 1 (IFNGR1), and interferon gamma receptor 2 (IFNGR2) in the pituitary were assessed. Results Monocyte...
Involvement of Interferon-Gamma Genetic Variants and Intercellular Adhesion Molecule-1 in Onset and Progression of Generalized Vitiligo. Shah BJ, Begum R (2013) Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in onset and progression of generalized vitilig... Dwived...
(i) said polypeptide is a Type II interferon or a Type II interferon-like molecule; (ii) said nucleic acid molecule comprises a sequence of nucleotides which is at least 40% identical to the nucleotide sequence set forth in SEQ ID NO:1; and ...
In studies of the molecular mechanisms by which these cells are regulated by IFN-gamma, the transcriptional activation of an IFN-gamma-inducible gene, gamma.1, in human macrophage-like cell lines was examined. Transcription of this gene is rapidly induced by 0.1-1 unit of IFN-gamma. In ...