Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection. During virus infection, ISGs impart antiviral actions to control virus replication and spread but can also contribute to disease pathology if ...
Of significance, in currently unpublished data, we have observed that >90% ofAGSpatients, of any genotype, sampled at any age, demonstrate a so-called “interferon signature” – i.e., increased expression of multipletype I interferonstimulated genes (ISGs) – in whole blood. Beyond the inter...
Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. The researchers identified 65 interferon-stimulated genes (ISGs) that act to dampen the infection. The studywas published in the journalMolecular C...
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mechanisms in viral ...
Some interferon stimulated genes (ISGs) encode proteins that inhibit LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-encoded protein (ORF1p) in ribonucleoprotein particles. Th...
Upon binding to their respective receptors, IFNs trigger signaling cascades that result in the transcriptional induction of sets of genes called interferon stimulated genes (ISGs). There are close to 300 known ISGs that limit every step of viral propagation by mediating a wide range of f...
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the...
Vet Res (2016) 47:75 DOI 10.1186/s13567-016-0363-8 RESEARCH ARTICLE Open Access Chicken interferome: avian interferon‑stimulated genes identified by microarray and RNA‑seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN‑α) Efstathios S. ...
Viral evasion of interferon stimulated genes. Viruses and their hosts since the dawn of time have been battling for supremacy. In recent years, the 'Interferon Gateway' encompassing interferon-alpha an... Short,John,L A. - 《Bioscience Horizons the National Undergraduate Research Journal》 被引量...
Our data show that many genes that are normally activated in response to interferon signaling (interferon stimulated genes, ISGs) are repressed when PR is activated by its ligand. Interestingly, this repression occurs even in the presence... K Walter,M Goodman,G Trinca,... - 《Cancer Research...