HDAC-targeting epigenetic modulators for cancer immunotherapy Binbin Cheng, ... Jianjun Chen, in European Journal of Medicinal Chemistry, 2024 Abbreviations used STING stimulator of interferon genes T cell immunoglobulin and ITIM domain PD-1 programmed cell death protein 1 PD-L1 programmed ce...
CONCLUSIONS: The present results suggest that the epigenetic silencing of IFN-stimulated genes is implicated in the acquisition of a partially IFN-resistant phenotype of HCV replicon-harboring cells.Naka KAbe KTakemoto KDansako HIkeda MShimotohno KKato N...
Interferon-γ (IFN-γ) primes macrophages to undergo proinflammatory activation. Ivashkiv and colleagues detail the translational and metabolic program triggered in human macrophages after IFN-γ treatment. Interferon-γ (IFN-γ) primes macrophages for e
Interferon-stimulated genes. Expression of human specific signalling genes (hSTAT 1, (A), interferon-stimulated genes (hMxA, (B) hISG15, (C) and cytokines (hCXCL10, (D) in HBV/HDV infected untreated and peg-IFNα, peg-IFNλ and ETV treated animals. Expression levels are relative the ...
80% (80/100) of DE genes also were associated with a non-DE (Figure S2H), suggesting that IFN-γ can repress genes by targeting more than one gene-associated enhancer by distinct mechanisms. We next tested whether enhancer disassembly had a role in the epigenetic “short term memory” ...
[11–13]. In reality, it is unlikely that the DS traits are caused by one genetic mechanism but instead are due to a combination of mechanisms, with the added complexity of further genetic and epigenetic controls [14]. Some researchers have suggested that dosage imbalance of certain genes ...
79: 175–200. J Virol 120: 2401–2410. J Virol81: 84–94. Uozaki H, Fukayama M . (2008). Epstein–Barr virus and gastric carcinoma—viral carcinogenesis through epigenetic mechanisms. Authors and Affiliations
Am J Transl Res Combined treatment with epigenetic agents enhances anti-tumor activity of T cells by upregulating the ACRBP expression in hepatocellular carcinoma 34377237 J Immunol Res Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus 34395633 Sci...
Type I interferon (IFN-I) plays a crucial role in the antiviral immune response and inflammatory autoimmune diseases by inducing the expression of IFN-stimulated genes (ISGs). Hence, the regulation of ISG expression is fundamental for maintaining immune homeostasis. In this study, we found that ...
genes (includingTLR7,IL13RA1andELF4) which were up-regulated in response to IFN-α stimulation (fold-change: 2.41;P = 6.0 × 10−9; ANOVA; Fig.5a). No other Xp21.1 gene was modulated by IFN-α. We profiled the epigenetic landscape surrounding theCXorf21locus in ENCODE data...