2013. Insulin signaling and insulin resistance. J Investig Med, 61, 11-4.Beale Elmus G.Insulin signaling and insulin resistance. Journal of investigative medicine : the official publication of the American Federation for Clinical Research . 2012...
Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth Factor (IGF) Signaling be used as a Therapeutic Target? Cardiac aging and insulin resistance: Could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target? Curr. Pharm. Des. 2013,... S Boudina...
展开 关键词: Animals Humans Insulin Resistance Insulin Protein-Serine-Threonine Kinases Protein Kinase C Receptor, Insulin Intracellular Signaling Peptides and Proteins Proto-Oncogene Proteins Phosphoproteins 被引量: 23 年份: 2000 收藏 引用 批量引用 报错 分享 全部...
This heterogeneous and multifactorial disease, also known as insulin resistance, is caused by the disruption of the insulin signaling pathway. In this review, we discuss the existence of various miRNAs involved in regulating the main protein cascades in the insulin signaling pathway that affect ...
Insulin combined with insulin receptor,can stimulate different signal transmission and induce different actions in cells of different tissues.So any kind of inhibition in insulin signaling may result in insulin resistance.Recently dysfunction of insulin receptor,insulin receptor substrates,PI?3K and so on...
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome Insulin resistance, obesity, diabetes, dyslipidemia and nonalcoholic fatty liver are components of the metabolic syndrome, a disease complex that is increa... K Ueki,T Kadowaki,CR Kahn -...
Results in cultured cells also showed that blunting signaling by the inhibitor LY-294002 prevented fat accumulation, oxidative stress, and resistance induced by the prolonged exposure to either or plus sera that normally contain . Finally, knockdown of the prevented the oxidative stress and resistance...
Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance. A mathematical model of the insulin signaling network (ISN) is proposed and used to investigate th...
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.Author(s): K Ueki, A Virkamäki, Valerie C Kahn Publication date: 1999-03-31 Journal: The Journal of clinical investigation Keywords: Animals, Gene Targeting, Humans, Insulin, metabolism, Insulin ...
Piccolo, S., Dupont, S. & Cordenonsi, M. The biology of YAP/TAZ: Hippo signaling and beyond.Physiol. Rev.94, 1287–1312 (2014). ArticleCASGoogle Scholar Barry, E. R. & Camargo, F. D. The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and...