Understanding the signaling pathways involved in insulin action could lead to a better understanding of the pathophysiology of insulin resistance associated with obesity and type 2 diabetes, and identifying key molecules and processes could lead to newer and more effective therapeutic agents for treating ...
Understanding "insulin resistance": Both glucose resistance and insulin resistance are required to model human diabetes A mathematical model of normal glucose/insulin homoeostasis has been based on the known, experimentally determined responses of the liver and periphery to ... AS Rudenski,DR Matthews...
Key findings C2C12 is a wellヾocumented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular levels. With the aid of the C2C12 model, recent ...
Despite advances in targeting oncogenic driver mutations, advanced-stage non-small-cell lung cancer (NSCLC) remains largely incurable due to therapeutic resistance. This Review focuses on how understanding the mechanisms of resistance to targeted therapi
Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible? A possible pathogenic mutation in the glucagon receptor gene causing a Gly to Ser change at codon 40 (Gly40Ser) was reported to be associated and linked wi... E Cerasi - 《Diabetologia》 被引量:...
The natural world is under unprecedented and accelerating pressure. Much work on understanding resilience to local and global environmental change has, so far, focussed on ecosystems. However, understanding a system’s behaviour requires knowledge of its
Increased signaling via the phosphatidylinositol 3-kinase/Akt pathway could contribute to trastuzumab resistance because of activation of multiple receptor pathways that include HER2-related receptors or non-HER receptors such as the insulin-like growth factor 1 receptor, which appears to be involved in...
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two. They can be activated by a repertoire of endogenous and exogenous stimuli, leadi
Insulin Resistance: Elevated cortisol can also lead to insulin resistance, a condition where the body’s cells become less responsive to insulin. This can result in higher blood sugar levels and increased fat storage. Muscle Breakdown: Cortisol can promote the breakdown of muscle tissue. Since musc...
The β3‐adrenoceptor: an advance in the understanding of obesity and insulin resistancedoi:10.5694/j.1326-5377.1996.tb138636.xRichard DonnellyDiabetes CentreRoyal Prince Alfred HospitalSydneyNSWJohn Wiley & Sons, LtdMedical Journal of Australia