Sesti G (2006) Pathophysiology of insulin resistance. Best Pract Res Clin Endocrinol Metab 20:665–679Federici M, Porzio O, Lauro D, et al. Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin ...
Accumulating evidence implies that MetS contributes to the development and progression of Alzheimer's disease (AD); however, the factors connecting this association have not been determined. Insulin resistance (IR) is at the core of MetS and likely represent the key link between MetS and AD. In...
Basal insulin secretion, however, is normal and milder degrees of glucose intolerance can be associated with a normal or supernormal insulin response to glucose; (2) insulin resistance is almost uniformly present in patients with any ... RA Defronzo,E Ferrannini,V Koivisto - 《American Journal ...
The etiologies of PCOS are not fully understood, but several possible hypotheses for the uterine manifestations observed in PCOS patients have been postulated to involve hyperandrogenism (androgen excess) together with obesity-related insulin resistance [6,7,8]. The majority of women with PCOS have...
association are limited. Different systemic alterations linked to obesity, including hormonal disturbances, insulin resistance, dyslipidemia or hyperglycemia induce carcinogenesis, but other factors, such as chronic inflammation, dysbiosis and altered intestinal barrier, have been recently considered of crucial ...
In addition previous studies have found leptin resistance concomitantly with high circulating leptin levels in obese patients. We hypothesize that calorie overconsumption can lead to increased proteolytic activity in the brain, promoting cleavage of key receptors governing food intake. Wister rats were ...
Amatruda JM , Chang CL 1983 Insulin resistance in the liver in fasting and diabetes mellitus: the failure of insulin to stimulate the release of a chemical modulator of pyru vate deh ydrogen ase. Biochem Bioph ys Res Comm 112:35 2. Amatruda JM , Finch ED 1979 Modulation ofhexo se up...
[3], leading to local and systemic insulin resistance (IR) and associated pathologies. AT, beyond storing energy as triacylglycerol (TAG)-filled lipid droplets, secretes various cytokines, hormones, and adipokines regulating whole-body energy metabolism. Recently, AT has been demonstrated to secrete ...
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance J Clin Invest 1995 95: 2409–2415. Article CAS Google Scholar Glaum SR, Hara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, Miller RJ . Leptin, the obese gene product, rapidly ...
INSULIN-RESISTANCEINFLAMMATIONOBESITYASSOCIATIONSMetabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn. The aim of this pilot study was to assess the correlation between activation of ...