The tissues have lost some of their sensitivity to insulin’s action. This critical concept is calledinsulin resistance. Insulin still has some effect on the tissues, but not as much as it should. Different diabetics have different degrees of insulin resistance, and you can’t tell by just lo...
BACKGROUND:The prevalence of metabolic (dysfunction)-associated fatty liver disease (MAFLD) increases together with the epidemic of childhood obesity. An important mechanism in the phenomenon appears to be insulin resistance (IR), the assessment of which
To examine influence of insulin resistance and other clinical risk factors for the MetS (metabolic syndrome) on vascular structure and function in young adults. This cross-sectional study was conducted in a cohort of young adults (mean age 22 years) and their siblings participating in a ...
population-based study conducted in Malmö, Sweden, we have previously reported that Middle Eastern immigrants from Iraq represent a high-risk population for type 2 diabetes and that diabetes-related risk factors such as family history of diabetes, obesity and insulin resistance cluster in this popu...
Indiana University School of Medicine, Division of Endocrinology and Metabolism, De- partment of Medicine, 541 North Clinical Drive, CL 459, In- dianapolis, IN 46202-5111, USA that the lump constant for [18]fluoro-2-deoxy-glucose does not change with insulin stimulation or insulin resistance....
Further research is required to ascertain the exact role of the hypothalamus in body weight changes and metabolic rate, and whether this is simply related to changes in food intake or more likely an interaction between intake, metabolic rate, and autonomic function. Insulin resistance and lipids: ...
(Fig.4a). The changes in the expression of these genes could, however, not be explained by lowered levels of the transcription factors as the protein levels of PPARγ, C/EBPα and C/EBPβ (a close relative of the C/EBPα) were not altered uponMdm2knockdown (Supplementary Fig.S4c) ...
Importantly, 43% of insulin-regulated sEV-miRNAs are implicated in obesity and insulin resistance. These include let-7 and miR-103, which we show regulate insulin signaling in AML12 hepatocytes. Together, these findings demonstrate an important layer to insulin’s regulation of adipose biology and...
leptin resistance – which may be part of an obesity-driven vicious cycle [72]. These observations could be partly explained by FOXO activity. Two recent pieces of research suggest that redox is integral to the appetite/anorexic mechanism, and integrate this action with the endocannabinoid system ...
certain cancers such as stomach, liver, pancreas, endometrium and kidney cancers in the population compared with the general population," Mao explained. "Whereas, in type 2 diabetes, increased risk is attributed to metabolic factors such as obesity, chronic inflammation status, andinsulin resistance....