the hormone may act in perfectly normal fashion in other cells. Even within a single cell, one secondaryinsulin signalingsystem may remain intact whereas another may be defective. Simply stated, when insulin resistance is present, somecellular processesmay be understimulated by insulin, whereas others...
In the insulin resistance state, three detrimental elements are present, the IR, the compensated peripheral hyperinsulinemia and the consequent hyperglycemia or glucose intolerance. Simply put, IR is the reduced response to insulin which can occur due to genetic and/or environmental factors [45]. ...
What else besides insulin resistance contributes to NASH? The process whereby liver inflammation and death of liver tissue develop in NASH remains to be clearly explained. Several theories, however, have been advanced. First, it is possible that the accumulation of fat in the liver alone could le...
The tissues have lost some of their sensitivity to insulin’s action. This critical concept is calledinsulin resistance. Insulin still has some effect on the tissues, but not as much as it should. Different diabetics have different degrees of insulin resistance, and you can’t tell by just lo...
Thus, the decline in PSA level in men with MS or IR can be also explained by increased plasma volume other than any intrinsic metabolic effects. OBJECTIVE: To investigate the detailed mechanism of prostate-specific antigen (PSA) decline in metabolic syndrome (MS) and insulin resistance (IR), ...
The metabolic score for insulin resistance (MetS-IR) has become a valid indicator to evaluate insulin resistance. Our investigation sought gender differences in the correlation between MetS-IR and the reversion from prediabetes to normoglycemic status. T
Subsequent injection of insulin does not alter the activity of either the PI 3-kinase or ERK signalling pathways, indicating a degree of neuronal molecular insulin resistance. However, if body temperature is maintained during anaesthesia then there is no alteration in the basal activity of these ...
BACKGROUND:The prevalence of metabolic (dysfunction)-associated fatty liver disease (MAFLD) increases together with the epidemic of childhood obesity. An important mechanism in the phenomenon appears to be insulin resistance (IR), the assessment of which
Insulin resistance after insulin-induced hypoglycaemia has also been ob- served in non-diabetic subjects [3-5]. Despite its wide- spread recognition as a common problem causing in- sulin resistance in insulin-treated patients, the excact mechanism of this phenomenon remains controversial [6-9]. ...
Further research is required to ascertain the exact role of the hypothalamus in body weight changes and metabolic rate, and whether this is simply related to changes in food intake or more likely an interaction between intake, metabolic rate, and autonomic function. Insulin resistance and lipids: ...