Insulin regulates a large number of metabolic functions across various organ systems. Therefore, reduced sensitivity to the action of insulin (ie, insulin resistance) represents a suboptimal biological response of different metabolic pathways to normal circulating insulin concentrations.43However, it has be...
The metabolic score for insulin resistance (MetS-IR) has become a valid indicator to evaluate insulin resistance. Our investigation sought gender differences in the correlation between MetS-IR and the reversion from prediabetes to normoglycemic status. T
Although HOMA-IR is a recognized indicator of insulin resistance (IR) in adults, in our study HOMA-IR did not differentiate well between children with and without MAFLD. Similar conclusions about the limited diagnostic value of this indicator, especially in the pediatric population, which lacks sta...
The tissues have lost some of their sensitivity to insulin’s action. This critical concept is calledinsulin resistance. Insulin still has some effect on the tissues, but not as much as it should. Different diabetics have different degrees of insulin resistance, and you can’t tell by just lo...
Young people with common mood disorders face the prospect of shortened life expectancy largely due to premature cardiovascular disease. Metabolic dysfunction is a risk factor for premature cardiovascular disease. There is an ongoing debate whether metabolic dysfunction can be simply explained by weight ...
population-based study conducted in Malmö, Sweden, we have previously reported that Middle Eastern immigrants from Iraq represent a high-risk population for type 2 diabetes and that diabetes-related risk factors such as family history of diabetes, obesity and insulin resistance cluster in this popu...
Further research is required to ascertain the exact role of the hypothalamus in body weight changes and metabolic rate, and whether this is simply related to changes in food intake or more likely an interaction between intake, metabolic rate, and autonomic function. Insulin resistance and lipids: ...
Presumably, pancreatic β cells and tissues that clear insulin sense the need to secrete more and clear less insulin to prevent hyperglycemia when there is insulin resistance, and this compensatory mechanism is im- paired in people with T2D [4–9]. Here, we provide an overview of the factors...
(Fig.4a). The changes in the expression of these genes could, however, not be explained by lowered levels of the transcription factors as the protein levels of PPARγ, C/EBPα and C/EBPβ (a close relative of the C/EBPα) were not altered uponMdm2knockdown (Supplementary Fig.S4c) ...
Among the possible binding sites with miR-486-5p, of note, Gsk3β, Trpm2, FoxO1 and Atf6 were finally picked out as functional genes, which are involved in insulin resistance signaling (Fig. 5G). Collectively, these results revealed that the normalized abundance levels of the plasma EVs ...