Most papers in the field describe polymer systems that can release insulin from subcutaneous (s.c.) depots in response to glucose fluctuations, but such systems are limited by delayed glucose diffusion to the subcutis, as well as a delay in the released insulin entering the blood circulation. ...
Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions
(the “Cori ester”) and a glycogen primer, catalyzed the synthesis of glycogen or, to be more precise, of an amylose-like, linear glucose polymer (branching had not yet been discovered) that gave a blue color with iodine instead of the normal mahogany tinge (the so-called “blue” ...
Polysaccharide—As used herein, a “polysaccharide” is a polymer of saccharides. The terms “polysaccharide”, “carbohydrate”, and “oligosaccharide”, may be used interchangeably. The polymer may include natural saccharides (e.g., arabinose, lyxose, ribose, xylose, ribulose, xylulose, allose, ...
PLGA nanoparticles are useful to protect and deliver proteins in a localized or targeted manner, with a long-term systemic delivery pattern intended to last for a period of time, depending on polymer bioerosion and biodegradability. However, the principal concern regarding these carriers is the ...
Glucose-responsive insulin is a therapeutic that modulates its potency, concentration or dosing relative to a patient’s dynamic glucose concentration. This Perspective summarizes some of the recent accomplishments in this field as well as discussing new
Both FPBAINP and FTBAINP have the potential for development as a glucose-selective insulin delivery system in physiological settings.doi:10.1080/09205063.2017.1301774Siddiqui, Nabil A.Billa, NashiruRoberts, Clive J.Taylor & Francis GroupJournal of Biomaterials Science, Polymer Edition...
A pharmaceutical carrier for the hydrophobic compounds of the invention is a co-solvent system comprising benzyl alcohol, a nonpolar surfactant, a water-miscible organic polymer, and an aqueous phase. Naturally, the proportions of a co-solvent system may be varied considerably without destroying its...