Induced pluripotent stem cells: origins, applications and Future perspectives. J Zhejiang Univ-Sci B. 2013; 14(12):1059-1069.Zhao J, W-j J, Sun C, C-z H, Yang X-m, Gao J-g (2013) Induced pluripotent stem cells: origins, applications, and future perspectives. J Zhejiang Univ Sci ...
Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells. Furthermore, our recent study demonstrated the generation of induced tissue-specific stem (iTS) cells by transient overexpression of the reprogramming ...
"Inducedpluripotent stem cellshave given us a window into human development unlike anything we had before," Kriegstein said. "I'm interested in the early development of the brain's cortex. Of course, we've never had unrestricted access to living human brain cells. Now we can takeskin cellsa...
Induced pluripotent stem cells (iPSCs) are produced from adult somatic cells through reprogramming, which behave like embryonic stem cells (ESCs) but avoiding the controversial ethical issues from destruction of embryos. Since the first discovery in 2006 of four factors that are essential for maintain...
Another obvious source is embryonic stem cells, but the complexity of the derivation technique and ethical issues have hindered advancement in clinical applications. The generation of human induced pluripotent stem cells (iPSCs) has opened a new avenue for patient-specific cell-based therapies [14]....
but can also avoid immune rejection in transplantation therapies. There are also no ethical issues, as autologous cells are used to generate iPSCs. Patient-specific iPSCs exhibit similar molecular profiling and pluripotent potential to that of hESCs, thus iPSCs can serve as an excellent disease mo...
Porcine Induced Pluripotent Stem Cells Produce Chimeric Offspring.Ethical and moral issues rule out the use of human induced pluripotent stem cells (iPSCs) in chimera studies that would determine the full extent of their reprogrammed state, instead relying on less rigorous assays such as teratoma ...
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be dif
Both ES cells and iPS cells are pluripotent stem cells with capabilities of indefinite self-renewal and can be differentiated into almost all cell types of the body, which make them valuable for studying early developmental biology, for modeling and as therapy for human diseases. Specifically, ...
The generation of induced pluripotent stem (iPS) cells from differentiated somatic cells offers innovative biomedical applications that are significantly advancing human medicine. Patient-specific iPS cells can self-renew indefinitely and serve as a limitless source of autologous cells to treat a number ...