The initial outcry over the potential use of somatic cell nuclear transfer (SCNT) to clone humans was followed by a broader debate about the ethics of the new avenues of medical research that had been opened by new technology, especially the potential to create human embryos that could be ...
but our knowledge of this crucial stage is limited by the inability to observe the embryo in vivo. Models of the embryo derived from stem cells are important tools for interrogating developmental events and tissue–tissue crosstalk during these stages1. Here we establish a model of the human ...
Human pluripotent stem cells (PSCs) can give rise to any cell type in the body. PSC derivatives are being developed for therapeutic use in diseases affecting organs and organ systems such as the eye, nervous system, heart, pancreas, liver, intestines, lung, circulatory system and skin, as ...
Hematopoietic progenitors are defined as undifferentiated pluripotent stem cells that are capable of self-renewal and can differentiate into all blood cell types, as well as lineage-committed progenitors that have a limited capacity for self-renewal and are thus committed to a specific cell lineage. ...
Ethical Aspects of Translating Research with Human Pluripotent Stem Cell Products into Clinical Practice: A Stakeholder ApproachStem cellsclinical trialethicsresearchstakeholdertranslational medicineExperimental therapies with embryonic stem cells (hESCs) and, more recently, human induced pluripotent stem cells (...
Embryonic stem cells (ESCs) are pluripotent stem cells that are derived from early embryos. Induced pluripotent stem cells (iPSCs) are somatic cell-derived reprogrammed cells that have equivalent characteristics to ESCs. Disease-specific iPSCs have started to be used for the investigation of and de...
Establishing an Australian Bank of Cord Blood‐Derived Induced Pluripotent Stem Cell Lines: Ethics, Re‐consent, and Progress Towards Cellular Therapies16doi:10.1002/sctm.12565Keren M. AbbertonThe BMDI Cord Blood Bank Victoria Australia Murdoch Children's Research Institute Victoria Australia University ...
J Luyten - 《Public Health Ethics》 被引量: 29发表: 2011年 Framing pluripotency: iPS cells and the shaping of stem cell science In the last decade, the pluripotency of human embryonic stem cells, i.e. their capacity to differentiate into any cell of the body and multiply endlessly, ......
The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of ...
Michael Armstrong Professor of Medicine at Johns Hopkins Medicine and Co-Director of the Stem Cell Program, of the Institute for Cell Engineering at Johns Hopkins Medicine. He is Co-Director of the Stem Cell Policy and Ethics (SCoPE) Program at the John Hopkins Berman Ethics Institute. Dr ...