The PD-1 gene was activated in both stimulated 2B4.11 and IL-3-deprived LyD9 cells, but not in other death-induced cell lines that did not show the characteristic features of the classical programmed cell death. Expression of the PD-1 mRNA in mouse was restricted to the thymus and ...
and western blot (Fig.1h) assays using an anti-PD-L1 antibody. DbA and BzP also upregulatedPD-L1in 16HBE cells (supplementary Fig.1), but the effects were much weaker than that induced by BaP. We therefore investigated the mechanisms of action of BaP-induced PD-L1 expression in this st...
5I). However, the protein expression of PD-1, PD-L1, CTLA-4, and PD-L1 was significantly elevated after the early and late stages of silica instillation, and both PI and CI treatment suppressed this elevation (Fig. 5J). These results indicated that spleen cells and the immune checkpoints...
enhanced PD-L1 expression in HaCaT cells, suggesting that NTP may inhibit unwanted over-activation of T cells through increased PD-L1 expression. Taken together, these results suggest that NTP may be used in treatment of CD4+ T cell-mediated autoimmune diseases such as psoriasis. Similar content ...
However, only a fraction of patients experience durable clinical responses, even when using multiple biomarkers including PD-L1 expression (Doroshow et al., 2021), mismatch repair deficiency (Le et al., 2017), and tumor mutational burden (Yarchoan et al., 2017) to screen for therapeutic ...
However, MKK1 inhibitors UO126 and PD98095 suppressed gene expression. Consistent with this, expression of dn-MKK1 strongly suppressed PMA-stimulated promoter activity, while the constitutively active MKK1 augmented it. However, MKK1-mediated induction of SPRR1B probably does not depend on ...
Chai X, Hu L, Zhang Y, et al. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv; 2020. Parohan M, Yaghoubi S, Seraji A. Liver injury is associated with severe coronavirus disease 2019 (COVID-19) infection: a systematic review and met...
of non-small cell lung carcinoma (NSCLC) patients demonstrated that the expression of immune checkpoints increased during the early stages of the culture. Although PD-L1, LAG-3, TIM-3, and CEACAM-1 remained at a high level during CIK culture, the expression of TIGIT, BTLA, PD-1, and ...
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but little is known about the molecular mechanisms controlling these even... G Mudò,Johanna ...
tumors, successful diffusion from tumor vessels, effective penetration into deep tumor tissues, and efficient internalization of anticancer drugs into both tumor cells and TRCs owing to the low expression of cytospin-A, a cytoskeleton-related protein. Beyond their improved tumor-targeted drug delivery ...