indole is considered as the most inquisitive scaffold for anticancer drug research.This is illustrated by the fact that the U.S.Food and Drug Administration(FDA)has recently approved several indole-based anticancer agents such as panobinostat,alectinib,sunitinib,osimertinib,anlotinib and nintedanib for ...
multidrug resistance-associated protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2), has been considered a pragmatic strategy for reinstating drug sensitivity in resistant cells when co-administered with anticancer drugs (Feyzizadeh et al. 2022...
Molecular modeling studies and physicochemical parameter calculations of the most active compounds confirmed their safe. drug-like properties. as a promising anticancer class. 展开 关键词: Ellipticine Synthesis Indole Antitumor screening Topoisomerase inhibitors Molecular modeling INTERMOLECULAR REACTIONS ...
As another aspect of the present invention, a combination of a compound of the present invention with another anticancer agent is envisaged, especially for use as a medicine, more specifically in the treatment of cancer or related diseases. For the treatment of the above conditions, the compounds...
Although compounds with excellent activity or for clinical research have not been obtained, this hybrid strategy can enhance the activity and selectivity of individual components, and it is worthy of application in new anticancer agents design. 2.1.2 Indolone derivatives Based on the structure of ind...
A. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorg. Med. Chem. Lett. 21, 1411–1413 (2011). 17 Andreani, A. et al. Imidazo[2,1-b]thiazole guanidinylhydrazones as RSK2 inhibitors. Eur. J. Med. Chem. 46, 4311–4323 (...
In recent years, a variety of indole alkaloids were isolated and evaluated for their anticancer activity. Some of them demonstrated promising efficacy against drug-sensitive and multidrug-resistant cancers in vitro and in vivo, suggesting their potential in the control and eradication of cancers. The...
Anticancer Drug Des 1989, 3: 249–254. Google Scholar Petit GR, Rhodes MR, Herald DL, Hamel E, Schmidt JM, Petit RK: Antineoplastic agents, 445, synthesis and evaluation of structural modifications of (Z), and (E)-combretastatin A-4. J Med Chem 2005, 48: 4087–4099. 10.1021/jm0205...
Several anticancer drugs, such as vincristine and vinblastine, are indoles, while indole derivatives continue to be explored as possible cancer-prevention targets. Indole derivatives and cellular signaling Many indole derivatives are AhR ligands, which determine the reactivity of AhR.AhR activation can ...
The combined application of VCR and berberine can also dramatically inhibit the growth of HCC cells as well as enhance the ability of apoptosis, which is related to mitochondrial dysfunction and ER stress induction, indicating that berberine is a powerful adjuvant anticancer drug. Besides, berberine ...