Natural products offer an abundant source of diverse novel scaffolds that inspires development of next generation anti-malarials. With this vision, a library of scaffolds inspired by natural biologically active alkaloids was synthesized from chiral bicyclic lactams with steps/scaffold ratio of 1.7:1. ...
The indole assay kit (Sigma Aldrich, USA) is based on a modified version of Ehlrich’s and Kovac’s reagents, which reacts with indole to produce a colored compound at 565 nm. The intensity of this colored compound is directly proportional to the indole in the sample. This kit is suitab...
Structural diversity, natural sources, and pharmacological potential of plant-based saponins with special focus on anticancer activity: a review Article 18 July 2020 Introduction Alkaloids are nitrogen-containing compounds that belong to one of the largest groups of natural products and are often linked...
5.2.7 INDOLE NATURAL PRODUCTS 5.2.7.1 Natural Products The complexity and diverse biological activity of indole natural products continues to be a major driving forces in the development of new synthetic methods and novel indole-based medicinal agents. Several reviews of indole natural products have ...
We report here a palladium-catalyzed enantioselective synthesis of indole-based atropisomers via an intramolecular dynamic kinetic C–H cyclization. The TADDOL-derived phosphoramidite ligand proves to be most efficient in this directing-group-free transformation, delivering products with up to 96:4 er....
Based on the discovery of a natural bis-indole compound demethylasterriquinone B1 (shown below), scientists attempted to design small-molecule insulin mimics by oral administration. Consequently, ZL-196 (34) was synthesized (Scheme 21) and more quinone derivatives were obtained for the evaluation...
Here we attempt to optimize stilbene 5c using computer-based drug design and synthesize derivatives with benzimidazole or indole group. Biological evaluation ... DE Durrant,J Richards,A Tripathi,... - 《Investigational New Drugs》 被引量: 16发表: 2009年 加载更多来源...
Based on functional aspects, cell death modalities can be classified into two types: accidental cell death (ACD) and regulated cell death (RCD). ACD is usually triggered by some uncontrollable factors, including chemical, physical, or mechanical stress. In contrast, RCD is a cellular process ...
A solid-phase Fischer indole synthesis of 2,3-disubstituted indoles involved a traceless silicon-based linker <05JCO130>. The Fischer indole synthesis was involved in the preparation of a variety of 2,3-fused indoles including indolo[2,3-a]carbazoles <05SL42, 05TL4839>, 4-oxocarbolines <...
Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery Keshab Bhattarai, ... Bikash Baral, in Advances in Genetics, 2021 2.6 Indole alkaloids One of the largest nitrogen-containing secondary metabolites with potential biological activities found in fungi is ...