Indole skeleton, being a privileged structure has been extensively used for the discovery of novel anticancer agents and the application of indole derivatives against breast cancer is well documented. The present article highlights the usefulness of indole linked heterocyclic compounds as well as the ...
Although compounds with excellent activity or for clinical research have not been obtained, this hybrid strategy can enhance the activity and selectivity of individual components, and it is worthy of application in new anticancer agents design. 2.1.2 Indolone derivatives Based on the structure of ind...
Conversely, the establishment of appropriate experimental models to evaluate the role of autophagy in vivo also has fundamental significance in evaluating the therapeutic effects and safety as new anticancer agents for cancer therapy. In summary, we hope that more indole-contain compounds or naturally ...
Alterations in glycosylation have also been implicated in many human diseases including the development and progression of cancer1, and malignancy-specific glycans have shown promise as potential biomarkers2. Unfortunately, our ability to study and develop diagnostics and therapeutics based on protein ...
cancer assays (Tables2and3), (iii) Since I3C and DIM derivatives such as 5,5′-Br2-DIM, the regulated cellular process associated with hallmarks of cancer, it could be essential to evaluate also these derivatives as anti-cancer agents, maybe in conjunct with DIM or I3C, and finally, (...
cancer that may affect mostly the muscles. The aim is to compare its effect when combined with other anticancer agents, including vincristine (Allen-Rhoades2024). Moreover, the use of vinorelbine as a second-line treatment of malignant pleural mesothelioma, a rare type of cancer that affects ...
Alternative approaches to anti-tumour agents which act by mechanisms other than the inhibition of DNA synthesis have the potential to display enhanced selectivity of action. In recent years it has been discovered that a cell may become cancerous by virtue of the transformation of a portion of ...
The compounds described herein are also potent antineoplastic agents and are therefore useful in treating or preventing various types of neoplastic diseases. Neoplastic diseases which can be treated by means of the present invention include, but are not limited to, biliary tract cancer; brain cancer,...
discovery of many new anti-angiogenic agents, including kinase insert domain-containing receptor (KDR, also known as VEGFR-2, vascular endothelial growth factor receptor-2) inhibitors some of which are currently under clinical evaluation (Jekunen, et al Cancer Treatment Rev. 1997, 23, 263-286.)...
Prodrugs are therapeutic agents, inactive per se but transformed into one or more active metabolites. Thus, in the methods of treatment of the present invention, the term “administering” shall encompass treating the various disorders described with the compound specifically disclosed, or with a ...