The tumour suppressor gene p53 is one of the most frequently mutated genes in lung cancer and these defects are associated with poor prognosis, albeit some debate exists in the lung cancer field. Despite extensive research, the exact mechanisms by which
The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract . Digestion 2009 ; 79 Suppl. 1 : 33 - 39 .The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract. Oki E,Zhao Y,Yoshida R,Egashira A,Ohgaki K,Morita M,Ka...
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is h...
In a high proportion of cancers lacking mutations, p53 function is compromised by other recognised mechanisms [1]. In virus-associated cancers, this may occur via interaction with virally encoded proteins resulting in sequestration or enhanced degradation of p53. MDM2 binds to p53 and promotes the...
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different cancers, which are closely related with tumor...
Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, like p53. We show that p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. These studies uncover a p53-Ptpn14...
Mutation of the p53 tumor suppressor gene, often accompanied by overexpression of mutant p53 protein, is the most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas of the ovary and endometrium, p53 overexpression is seen in approximately 10% to 15% of early ...
In cancers with intactTP53gene, the functional protein is inactivated by overexpressed mouse double minute 2 (MDM2) and/or MDM4 which bind to the N-terminal domain and inhibit the transcriptional function of p53, or promote p53 mono- and/or polyubiquitination and nuclear export and proteasomal d...
Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy W-J Lu1, NP Lee1, SC Kaul2, F Lan3, RTP Poon1, R Wadhwa*,2 and JM Luk*,1,4,5 Stress protein mortalin is a multifunctional protein and is highly expressed in cancers. ...
Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and is initially very responsive to platinum-based chemotherapy. However, the majority of patients relapse following initial surgery and chemotherapy, highlighting the urgent need to develop new therapeutic strategies. ...