Linked channels through contiguous cell membranes that interconnect the cytoplasm of adjacent cells and allow direct exchange of ions and small molecules. About this article Cite this article Gatenby, R., Gillies, R. Why do cancers have high aerobic glycolysis?.Nat Rev Cancer4, 891–899 (2004)...
p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-...
Over the past decade, cancer stem cells have emerged as the centerpiece of cancer research, having a major role in resistance to conventional therapy and in the metastatic spread of tumours. The authors discuss the biological complexity of this subpopula
Recent advances in molecular oncology and genetics have led to such novel therapies as p53 gene therapy, which we are currently evaluating in a clinical protocol in patients with locally advanced (nonmetastatic) prostatic cancer. Ad5CMVp53 (RPR/INGN 201) has previously shown promise in both ...
Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome. 仅用于科研。不用于诊断过程。未经明确授权不得转售。生物信息学 蛋白别名: Antigen NY-CO-13; Cellular tumor antigen p53...
Promoting p53's function, without causing damage to the genome is widely accepted as a way to improve treatment of cancer. In the case of tumours where the p53 gene is not mutated or absent, there have been important advances in the recent past. Small molecules that, like the nutlins ...
K. Lam, Raymond Lai, Margaret Ip Class III β-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel Pascal Sève, John R. Mackey, Sylvie Isaac, Olivier Tredan, Pierre-Jean Souquet, Maurice Pérol, Raymond Lai, Alain ...
Antigen-specific cytotoxic CD8 T cells are extremely effective in controlling tumor growth and have been the focus of immunotherapy approaches. We leverage in silico tools to investigate whether the occurrence of mutations in proteins previously describe
Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia Cancer Genetics and Cytogenetics, Volume 66, Issue 2, April 1993, Pages 128–129 PDF (163 K) Coexpression analysis of c-Myc related genes NM23, Max, Mad, Mxi, c-fos, c-jun and c-myb in small cell lung canc...
p53 is mutated in nearly 50% of cancers, and mutations can alter the oligomeric state of the protein, having an impact on the biological function of the protein and on cell fate decisions. Here, we describe the effects of a number of representative cancer-related mutations on tetramerisation...