This serum marker is also useful for the detection of p53 protein overexpression and for the monitoring of residual tumor cells. Cancer 2000;89:1677鈥 83. 2000 American Cancer Society.doi:10.1002/1097-0142(20001015)89:8<1677::AID-CNCR5>3.0.CO;2-9...
Like its TAD, the PRD is dispensable for the ability of p53 to bind to DNA. Although there is evidence that the PRD is required to efficiently suppress colony formation of tumor cells in vitro [24], there are more convincing data that deletion of the PRD does not interfere with the ...
Cells were then treated with Kyn for another 48 h, followed by analysis of luciferase activity. f, The same as d. Runx1b and Runx1c expression levels were detected by RT–qPCR. g, MEPs from Ahr–/– mice were treated with Kyn for 48 h, and RUNX1 expression was determined by ...
产品特性This is a rabbit polyclonal antibody against TRP53. It was validated on Western Blot using a cell lysate as a positive control. 纯化方法Protein A purified 目标详细情况 别名TRP53 背景Trp53 is a protein found in elevated levels in a great variety of transformed cells ...
12, 13 Furthermore, some of these cells can also resume growing.14 Therefore, only those tumor suppressor genes which have the capacity to efficiently induce tumor cell death should be considered as good candidates for tumor suppressor gene therapy. The p53 gene has an attractive apoptotic tumor...
9 Cell & Bioscience REVIEW Open Access The regulation of cellular metabolism by tumor suppressor p53 Yingjian Liang†, Juan Liu† and Zhaohui Feng* Abstract As a hallmark of tumor cells, metabolic alterations play a critical role in tumor development and could be targeted for tumor therapy....
Fig. 2: Roles of p53 in renal fibrosis. In response to nociceptive stimulus, p53 is activated in the renal tubular epithelial cells to accelerate cell senescence, whereas inactivated in renal fibroblasts delays cell apoptosis, all of which promote the activation of myofibroblasts and renal fibrosis...
At the opposite, no ceramide increase was observed for the radioresistant U87MG and SQ20B cell lines whatever the type of irradiation used. Concerning the late ceramide production, in the radiosensitive SCC61 p53-mutated cells, irradiation induced a time-and LET-dependent increase in ceramide ...
Similarly, tumor xenografts or cells expressing highlevels of EGFR were successfully transfected with the gene using the GE11 peptide. Let-7a, a tumor-suppressingmiRNA, was delivered to cancer tissues expressing EGFR using genetically modified GE11-positive exosomal vaccines, which dramatically reduced ...
CD8+ cytotoxic T-cells specific for WT p53 peptides have been detected in the circulation of patients with WT or mutant p53-positive cancer (Chikamatsu et al., 1999, 2003; Ito et al., 2006; Rojas et al., 2005). However, a study performed with patients having p53 positive head and nec...