dictators, the recent eugenic excesses of the twentieth century and the brave new world held out by the imminent completion of the Human Genome Project provide rich and fertile ground for speculation, debate and sometimes concern. On the other hand, genetics offers the capacity to identify ...
The Human Genome Project has revealed that there are probably about 20,000-25,000 'haploid' protein coding genes. The completed human sequence can now identify their locations. But only about 1.5% of the genome codes for proteins, while the rest consists of non-coding RNA genes, regulatory s...
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable STR loci are known, some of which regulate gene expression and influence complex traits, such as height. Moreover, variant...
The way in which the genome is organized at different scales is a longstanding topic of investigation. The development of high-throughput chromatin conformation assays (for example, Hi-C1and ChIA-PET2) has substantially furthered our understanding of the 3D organization of the human genome and how...
Copy-number polymorphism: A CNV that occurs inmore than 1%of the population. Originally, this definition was used to refer to all CNVs Segmental duplication or low-copy repeat: A segment of DNA >1 kb in size that occurs in two or more copies per haploid genome, with the different copies...
- 《Genome Research》 被引量: 490发表: 2002年 Long Contiguous Stretches of Homozygosity in the Human Genome Single nucleotide polymorphisms (SNPs) are the most common sequence variation in the human genome; they have been successfully used in mapping disease gene... LH Li,SF Ho,CH Chen,......
The human,genome,sellout The 'bioinformatics'gold rush The reality test Will it deliver? ReferencesGovernments,in the industrialized countries have handed over the human,genome,to private ownership together with the most triumphant hyperboles to boot, notwithstanding that it was mapped,and sequenced,at...
Those working on the Human Genome Project claim something. 子句类型: 主句 连接词: 分句-1 The new genetical anatomy will transform medicine and reduce human suffering in the twenty-first century. 子句类型: 宾语从句 连接词: THAT 3. 句子成分 主句 Those [主语] working on the Human Genome...
This has been the year of agenda-setting conferences for the ambitious ELSI (ethical, legal and social issues) program of the Human Genome Project (HGP). But of the dozen or more major meetings of this sort held across the country, the one held at the National Institutes of Health (NIH...
Many coding regions in the human genome do not show an excess of low-frequency alleles. This indicates that balancing selection might be more common than generally perceived. The wealth of nucleotide polymorphism data that has become available during the past few years has provided an exciting oppo...