Finally, we analyzed the type, structure, and regulation of repeats in the human genome and their role in the induction of complex diseases. We believe that this review will facilitate a comprehensive understanding of repeats and provide guidance for repeat annotation and in-depth exploration of ...
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable STR loci are known, some of which regulate gene expression and influence complex traits, such as height. Moreover, variant...
Dolgin E. The most popular genes in the human genome. Nature. 2017; 551(7681):427-31. Epub 2017/ 11/24. https://doi.org/10.1038/d41586-017-07291-9 PMID: 29168817.Dolgin, E. The most popular genes in the human genome. Nature 551, 427-431, http://www.nature.com/doifinder/...
The Human Genome Project has revealed that there are probably about 20,000-25,000 'haploid' protein coding genes. The completed human sequence can now identify their locations. But only about 1.5% of the genome codes for proteins, while the rest consists of non-coding RNA genes, regulatory s...
“I think the defining challenge of human biology for this century is to understand which of these 3 million differences actually matter, and if they matter, how they matter,” Rine says. His ultimate goal is to understand what he calls “the good news in the human genome” — variants in...
HIV-1 integration in the human genome favors active genes and local hotspots. A defining feature of HIV replication is integration of the proviral cDNA into human DNA. The selection of chromosomal targets for integration is crucial f... ARW Schr?Der,P Shinn,H Chen,... - 《Cell》 被引量...
Evolutionary rates are not constant across the human genome but genes in close proximity have been shown to experience similar levels of divergence and selection. The higher-order organisation of chromosomes has often been invoked to explain such phenomena but previously there has been insufficient data...
D The Human Genome Project is one of the greatest explorations in human history, and it only takes 13 years for scientists from different countries to complete this huge project and draw the genetic map of human beings. The scientific and medical communities are very excited about the chances ...
不久之后,soon we will be able to use genome editing to increase the human resistance我们将能利用基因组编辑提高人体对感冒和流感的抵抗力,to colds and flu, to make people taller, to help their muscles develop也能让人长得更高、肌肉生长得更快,faster, to sharpen all of their senses or to ...
it is passed down during reproduction. The map marks a major step in understanding genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease....