Since the early days of the genome era, the scientific community has relied on a single ‘reference’ genome for each species, which is used as the basis for a wide range of genetic analyses, including studies of variation within and across species. As s
L. Pan-genomics in the human genome era. Nat. Rev. Genet. 21, 243–254 (2020). Article CAS PubMed PubMed Central Google Scholar Rhie, A. et al. Towards complete and error-free genome assemblies of all vertebrate species. Nature 592, 737–746 (2021). Article CAS ADS PubMed PubMed...
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to a pangenome form, but populations of Asian ancestry are underrepresented. Here we present data from the first phase of the Chinese Pangenome Consortium, including
意外找到了解析扇贝性染色体转换机制的突破口9(文章背后的故事:The ‘forever-young’ secret of scallop sex chromosomes: exceptions to the ‘general’ rules),这暗示我们将功能基因组学数据融入基因组共线性的分析流程,或许能够更好的...
18.Przybyla, L., Gilbert, L.A. A new era in functional genomics screens. Nat Rev Genet. 23, 89–103 (2022). 图文| 于洪伟 编辑| 田鑫 责编| 田鑫 审核| 一审:赵可欣 李叶 黄文蔚 二审:王贵宁 三审:贾希望
Illumina: Whole genome data, 300x PCR-free Illumina 150bp + 40x PCR-free 250bp, from GIAB All HG002 data (and links to parental data) are posted at the following Amazon AWS public dataset:human-pangenomics. In addition, we will host links to the following parental data: PacBio (HiFi...
Although CDKN2A alteration has been explored as a favorable factor for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) and intragenic deletion (DEL) and response to immune checkpoint inhibitors (ICIs) is still disputed.
into the evolutionary and domestication history of peach [27]. Recently, the advent of pangenomics has ushered in a transformative era in plant research, offering a comprehensive view of genetic diversity and evolutionary dynamics within species. Since the first plant pangenome analysis in soybean [...
The GSCA database serves as a pivotal resource in cancer research as it encompasses a wide array of gene set analyses, ranging from genomics, and pharmacogenomics to immunogenomics. Notably, CNV pie charts derived from this database reveal prevalent patterns, indicating that most cancers exhibit he...
The high-quality genome assemblies of 17 representatives developed and their good complementarity to the 10+ pan-genomes offer a robust platform for future genomics-assisted breeding in wheat. This is a preview of subscription content, access via your institution Access options Access Nature and 54...