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Extracellular vesicles (EVs) have emerged as key players in intercellular communication, facilitating the transfer of crucial cargo between cells. Liquid biopsy, particularly through the isolation of EVs, has unveiled a rich source of potential biomarkers for health and disease, encompassing proteins and...
A decade ago, landmark studies demonstrated that tetraspanin and TSG101-positive sEVs isolated from human blood contained genomic DNA (gDNA) representing the entire genome of the host cell [9,22,23] (Table1). These studies, performed on EVs isolated from cancer patients, demonstrated that sEV-...
Ten years ofGenome Medicine Charles Auffray, Julian L. Griffin, Muin J. Khoury, James R. Lupski and Matthias Schwab Genome Medicine201911:7 EditorialPublished on:15 February 2019 Full Text PDF Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations ...
Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and deregulated expression of epigenetic regulators in MB highlight the substantial role of epigenetic alt
Principal component analysis showed substantial similarity of 5hmC patterns in normal cerebella (n = 6) regardless of age (mean age = 11.5 years old, range = 5 to 19 years old), but tumors (n = 16, mean age = 9.4 years old, range = 1.5 to 34...
In recent years, the development of the next-generation genome sequencing technologies and open-source cancer gene expression profiles, such as The Cancer Genome Atlas (TCGA) project, has dramatically advanced the field of data mining-based studies to identify novel prognostic biomarkers. Thus, ...
Hundred years of genetic structure in a sediment revived diatom population. Proc Natl Acad Sci USA. 2011;108:4252–7. Article PubMed PubMed Central Google Scholar Whittaker KA, Rynearson TA. Evidence for environmental and ecological selection in a microbe with no geographic limits to gene flow...
Miller JD, McMullin DR (2014) Fungal secondary metabolites as harmful indoor air contaminants: 10 years on. Appl Microbiol Biotech 98:9953–9966 CAS Google Scholar Miller JD, Rand TG, Jarvis BB (2003) Stachybotrys chartarum: cause of human disease or media darling? Med Mycol 41:271–291 ...
Since the times of domestication, cattle have been continually shaped by the influence of humans. Relatively recent history, including breed formation and the still enduring enormous improvement of economically important traits, is expected to have left