Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types...
The pan-cancer analysis of whole genomes The expansion of whole-genome sequencing studies from individual ICGC and TCGA working groups presented the opportunity to undertake a meta-analysis of genomic features across tumour types. To achieve this, the PCAWG Consortium was established. A Technical Work...
Pan-cancer analysis of whole genomes Description of the PCAWG resource of >2,600 whole cancer genomes and their matching normal tissues across 38 tumour types, including data, portals, analysis pipelines and downstream integrative analyses. Afull list of authors (pdf 482 kb)is available for downlo...
is of whole genomes Pan-cancer analysis of whole genomesPan-cancer analysis of whole genomesGarry D CookAdam C LiedloffNicholas J Cuff
BMC Bioinformatics (2022) 23:298 https://doi.org/10.1186/s12859-022-04840-6 BMC Bioinformatics RESEARCH Open Access Pan‑cancer integrative analysis of whole‑genome De novo somatic point mutations reveals 17 cancer types Amin Ghareyazi1, Amirreza Kazemi1,2, Kimia Hamidieh3, Hamed...
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium Pan-cancer analysis of whole genomes Nature, 578 (2020), pp. 82-93, 10.1038/s41586-020-1969-6 Google Scholar Iliev et al., 2012 I.D. Iliev, V.A. Funari, K.D. Taylor, Q. Nguyen, C.N. Reyes, S.P. Strom, J. Brown, ...
The exceptions were acute myeloid leukemia (AML) and thyroid cancer, which predominantly showed low counts of all three signatures. For AML, this is consistent with the finding published by the TCGA consortium that this cancer type has relatively stable genomes with an average of just one somatic...
Although federated cooperation is politically desirable, uniform data quality and standards are essential and should not be reinvented from scratch. The International Cancer Genome Consortium (ICGC) will do well to start with the data standards of The Ca
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppress...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subt