Gravel, 2015 Estimating the mutation load in human genomes. Nat. Rev. Genet. 16: 333-343.Henn, B.M.; Botigue, L.R.; Bustamante, C.D.; Clark, A.G.; Gravel, S. Estimating the mutation load in human genomes. Nat. Rev. Genet. 2015, 16, 333-343. [CrossRef] [PubMed]...
Only approximately 20% of patients have a mutation in one of the alleles of the UROD gene, which can cause a reduction in the activity of enzyme ⑤ to less than 20% [4]. PCT is also considered an iron-related disorder. The disease becomes active when patients are exposed to predisposing...
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The impact of environmental and endogenous damage on somatic mutation load in human skin fibroblasts. PLoS Genet. 12, 1–25 (2016). Article CAS Google Scholar Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495–501 (2014). ...
The number of chromosomes in a human being is fixed at birth. After confirming that these chromosomes are ETs, comprehensive health examinations can be carried out. Those who are physically and mentally fit have the upper hand when it comes to having children. An iterative procedure with the ...
More than 90% of the adult population globally is chronically infected by the Epstein–Barr virus (EBV). It is well established that EBV is associated
Gravel, 2015 Estimating the mutation load in human genomes. Nat. Rev. Genet. 16: 333-343.Henn BM, Botigue´ LR, Bustamante CD, Clark AG, Gravel S. Estimating the mutation load in human genomes. Nature Reviews Genetics. 2015; 16(6):333-43. https://doi.org/10.1038/nrg3931 PMID: ...
Tumour mutation burden and other exome-wide biomarkers are used to determine which patients will benefit from immunotherapy. However, the cost of whole exome sequencing limits the widespread use of such biomarkers. Here, we introduce a data-driven framew