2012. Mutation load: the fitness of individuals in populations where deleterious alleles are abundant. Annu Rev Ecol Evol Syst. 43:115-135.Agrawal, A. F., and M. C. Whitlock, 2012 Mutation load: the fitness of individuals in populations where deleterious alleles are abundant. Annu. Rev. ...
1995. Mutation accumulation and extinction of small ... M Lynch,CR Burger - 《American Naturalist》 被引量: 0发表: 1995年 MUTATION LOAD AND THE SURVIVAL OF SMALL POPULATIONS Previous attempts to model the joint action of selection and mutation in finite populations have treated population size ...
Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula...
‘Ghost cities’ are a well-known phenomenon of (almost) complete vacancy of urban living space in China. Underutilization of urban living space, however, is far more common than complete vacancy. Here we propose the concept of housing utilization efficiency (HUE) and present the following findin...
MUTATION LOAD AND THE SURVIVAL OF SMALL POPULATIONS Previous attempts to model the joint action of selection and mutation in finite populations have treated population size as being independent of the mutati... LW Gabriel - 《Evolution》 被引量: 862发表: 1990年 COMPENSATING FOR OUR LOAD OF MUTA...
The nucleotide mutation rate was estimated to be 4e-9 based on M. sinica as a reference. According to cultivation records from the KBG, it takes approximately 30 years for the M. lacei plants propagated from seeds, to reach the mature phase of flowering and fruiting [24]. These data ...
This is termed the mutation load or tumor mutational burden (TMB). It is hypothesized that highly mutated tumors are more likely to harbor neoantigens which make them targets of activated immune cells. This metric has been shown, in several tumor types, to correlate with patient response to ...
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-cell transcriptomics data across six common can
Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies Viral kinetics, stability and sensitivity analysis of the within-host COVID-19 model 19 July 2023 Mutation induced infection waves in diseases like COVID-19 ...
The in silico analysis with MutationTaster220 did not predict any specific effects for the SNVs in exon 4. Thus, they were not considered for subsequent functional studies. The association signals with the smallest P values were observed for the two intronic SNVs rs4946935 (Pcent = ...