genetic load (redirected fromMutation load) Medical Encyclopedia genetic load n. 1.The relative difference between the theoretically most fit genotype within a population and the average genotype. 2.The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population an...
Mutation load and the extinction of large populations In the time evolution of finite populations, the accumulation of harmful mutations in further generations might lead to a temporal decay in the mean fitnes... AT Bernardes - 《Physica A-statistical Mechanics & Its Applications》 被引量: 23发...
The nucleotide mutation rate was estimated to be 4e-9 based on M. sinica as a reference. According to cultivation records from the KBG, it takes approximately 30 years for the M. lacei plants propagated from seeds, to reach the mature phase of flowering and fruiting [24]. These data ...
my teacher Mr. Smith announced an exciting project that each student would have a month to complete. We were expected to choose our materials, construct a small building and make use of things we had learned in class. Not only would the ...
The definitions and concepts used here are those used in their work. Under the assumption that a detrimental mutation occurs irreversibly, the mean and the variance of the "mutation load" due to such mutations, for finite populations can be obtained by the same calculations. (For the mutation ...
The number of small companies in each state – potentially at higher risk of bankruptcy than their larger counterparts – and their number of hospital beds per 1,000 residents were among the other variables considered. The 10 most vulnerable states include representatives from the Northeast, the We...
Small populations are often exposed to high inbreeding and mutational load that can increase the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is now restricted to small and isolated populations on Sumatra and Borneo, and most likely extinct on the Malay Peninsula...
Patients with LUSCs tend to be smokers and have aTP53mutation; whereas, LUAD patients have several key mutations inEGFR,KRAS,NRAS,BRAF,PIK3CA,MET, andCTNNB1genes4,5. Although the somatic mutations in each NSCLC subtype have been well-characterized, the fundamental differences in NSCLC micro-en...
MUTATION LOAD AND THE SURVIVAL OF SMALL POPULATIONS Previous attempts to model the joint action of selection and mutation in finite populations have treated population size as being independent of the mutati... LW Gabriel - 《Evolution》 被引量: 863发表: 1990年 Genome sequence of the enterobacteri...
Following manufacturer’s protocol the Chromium Controller (10X Genomics, PN-120223) was used to load 30,000 cells into a Chromium Next GEM chip G Single Cell Kit (10X Genomics, PN-1000120) to generate single cell gel beads in the emulsion (10X Genomics, PN-1000121). The cDNA and library...