Discovery biological motifs plays a fundamental role in understanding regulatory mechanisms. Computationally, they can be efficiently represented as kmers, making the counting of these elements a critical aspect for ensuring not only the accuracy but als
In order to investigate mutations in the protein-coding genes, a total of 76 commonly shared protein-coding genes in the ten PJ plastomes were analyzed. Forty-six of the shared genes contained variants, while the remaining 31 genes were identical among the PJ plastomes (Fig.2B). Among the 4...
Insects use sex pheromones as a reproductive isolating mechanism to attract conspecifics and repel heterospecifics. Despite the profound knowledge of sex pheromones, little is known about the coevolutionary mechanisms and constraints on their production
HNPCC is caused by loss-of-function germline mutations in a set of genes involved in the repair of DNA base pair mismatches that occur during DNA replication (also known as the mutation mismatch repair system). The genetic basis of HNPCC (Lynch syndrome) is described in greater detail in...
48while deletions can occur in the diploid without lethal effects because of the additional presence of the wild-type genome34. In addition, the possibility of the occurrence of LOH and aneuploidy events have been demonstrated by sequencing nine SCRaMbLEant colonies (Fig.5). This might also be ...
These are particularly useful for large-scale studies aiming to explore genetic variation across whole populations or for rapid screening of specific mutations. However, they necessitate prior knowledge of the expected allelic forms in the individuals being genotyped. Alternatively, genomic reduction ...
DNA mutations may occur during DNA replication resulting in changes to the codons and, by extension, the proteins they code for. Word count: 66 1. Frameshift mutations occur when nucleotides are added or deleted, changing where the three codon reading frame begins. Cystic fibrosis is an ...
We split the dataset into patient-wise training, validation, and internal test sets stratified by the target label, thus ensuring that every patient can only occur in one of these sets. The external test sets always consisted of different cohorts to better quantify the generalization properties of...
(1) the SPARCED model formalism can be used for simple implementation of large-scale mechanistic model-based hypotheses testing, (2) crosstalk between IFNγ and EGF pathways may occur through SOCS1 sequestration of activated receptor domains, and (3) SOCS1-induced inhibition of AKT and MAPK ...
Identifying open reading frames (ORFs) being translated is not a trivial task. ProTInSeq is a technique designed to characterize proteomes by sequencing transposon insertions engineered to express a selection marker when they occur in-frame within a prot