It was interesting to note that, amongst the six that did not display a significant effect was a lncRNA, AC087463.1, herein named LOHAN1 (LncRNA Oncogene in Head and Neck cancer—ENST00000568541 at the PWRN1 locus), which appeared as a potential driver in the Head and Neck (HN) tumour ...
To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most of them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether and how they could cause tumors re
Population-level dynamics of mutations in 10 frequently hit genes show consistent patterns. For each panel,achemostat 1,bchemostat 2, andcchemostat 3, the elapsed number of generations is depicted on thex-axis; the height of each gray box within each panel represents a frequency of 100%. Cum...
BMC Evolutionary Biology volume 8, Article number: 138 (2008) Cite this article 14k Accesses Metrics details Abstract Background Microsatellites are frequently used genetic markers in a wide range of applications, primarily due to their high length polymorphism levels that can easily be genotyped by ...
Since the first discovery of cancer-associated loss of DNA methylation, the field of cancer epigenetics has grown remarkably and helped elucidate aspects of cancer biology where genetic explanations alone are insufficient (Feinberg and Vogelstein,1983). Epigenetics is the process by which cells encode ...
Similar to genes, miRNA are not isolated, instead they act together to perform biological functions [35,36]. To understand how miRNA regulate biological processes at a system level, we used Lasso algorithms for a Gaussian graphical model to map the simultaneous expression of miRNA into a coexpre...
Marked acanthocytosis with a hemoglobin level of 12.8 g/dL was found. The duodenal mucosa appeared white endoscopically and the cytoplasm of the enterocytes was vacuolated. TABLE 1.. Clinical characteristics of patients with abetalipoproteinemia Family (Country)Age/SexCholesterolTriglycerideHDL-...
总的来说,adult human HSPCs show a large spectrum of mtDNA mutational diversity, and these mutations are stably propagated in daughter cells at a level that allows for lineage or clonal-tracing studies ofin vivohuman hematopoiesis. Figure 5 Mitochondrial Mutations Are Stably Propagated in Primary ...
However, a direct demonstration that crosstalk influences the evolution of signaling proteins and, more importantly, an understanding of how this occurs at the amino acid level are lacking. To tackle these challenges, we examined the evolution of two-component signal transduction proteins in bacteria....
theKRASmutation in a tumor sample. This value accounts for the level of each mutational signature in the tumor sample, and the ability of the mutational signature to cause the indicatedKRASallele. Incandd, onlyKRASalleles found in at least 15 tumor samples of the cancer type are included. ...