genetic and the epigenetic codes in tumour cells. The number of alterations seen in the coded programs increases as tumours progress to more advanced stages. Their existence and accumulation also explain why principles of evolutionary theory provide insights of practical significance for cancerbiology. ...
A theoretical framework based on the diffusion equation method was used to treat some problems of population genetics at the molecular level. To represent the mode of production of molecular mutants, two models were considered. One is th... M Kimura - 《Theoretical Population Biology》 被引量:...
S1b). Similar to the RE model, a P value is obtained by comparing the number of simulations with an exonic mean functional score higher or equal to the observed value (Formula 2). This module work with any base-level scoring method. Given its previous successful use and integrative nature...
4 Coding mutations influence the mRNA level of the mutated gene. a, Non-significant negative correlation between the mean fitness of synonymous mutants of a gene and the expression level of the gene. Each dot represents a gene. Spearman’s correlation ρ and associated P-value are presented. ...
Our study provides a novel method that is used to investigate the effects of gene mutations at the cellular level. Introduction Site-directed mutagenesis is one of the most important experimental techniques in molecular biology and is widely used to investigate the structure and function of DNA and...
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. Nat Rev Cancer. 2019;19(9):495–509. PubMed PubMed Central CAS Google Scholar Roeper J, Christopoulos P, Falk M, Heukamp LC, Tiemann M, Stenzinger A, et al. TP53 co-mutations as an independent ...
a... C Délye,F Pernin,L Scarabel - 《Plant Science An International Journal of Experimental Plant Biology》 被引量: 89发表: 2011年 Genetic Analysis of Imidazolinone Resistance in Mutation-Derived Lines of Common Wheat The imidazolinone herbicides possess high biological potency at low ...
[40] as a result of theIDH1mutation. Interestingly, the percentage of the predicted MGPs associated with lipid metabolism was remarkably different between two sarcomas, SoftTissue-Liposarc and SoftTissue-Leiomyo, and this different metabolic composition appeared to be consistent with their biology [...
To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most of them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether and how they could cause tumors re
Genetic instability, a heritable increase in the rate of genetic mutation, accelerates evolutionary adaptation1 and is widespread in cancer2,3. In mammals, instability can arise from damage to both copies of genes involved in DNA metabolism and cell cycl