Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, Europea
Animals such as raccoon dogs, mink and muskrats are farmed for fur and are sometimes used as food or medicinal products1,2, yet they are also potential reservoirs of emerging pathogens3. Here we performed single-sample metatranscriptomic sequencing of internal tissues from 461 individual fur animal...
Klarin, D. et al. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Nat. Genet. 55, 1106–1115 (2023). CAS PubMed PubMed Central Google Scholar Dobrin, P. B. & Mrkvicka, R. Failure of elastin or collagen as possible critical conn...
equivalence in lung habitat similarity between children and adult patients with CF, primarily resulting from the cumulative effects of CF pulmonary disease experienced with increasing age along with the spectrum of disease severity dictated by the CFTR mutations that individual patients have inherited [1...
We found that the majority of the AT-TTUs (> 96%) resided in approximately 1.4 million colonies, spread throughout the human genome. In comparison to the CG-TTU colonies, the AT-TTU colonies were significantly more abundant and larger in size. Pure units and overlapping units of the pu...
Len Schleifer describes how Regeneron raised its first $1 million The audio player is not supported by your browser. Transcript Len Schleifer explains how Regeneron got its name "There may be no other thing you can do that is more rewarding than to really move the human condition forward." ...
repetitive elements may comprise over two-thirds of the human genome重复的元素可能由超过三分之二的人类基因组 Repetitive Elements May Comprise Over Two-Thirds of the Human Genome 1 1¤ 1 2 1 A. P. Jason de Koning , Wanjun Gu , Todd A. Castoe , Mark A. Batzer , David D. Pollock *...
Specifically, we observed the emergence and continuous expansion of strains belonging to the dominant ST2096 in the CC14 clade across hospital wards in recent years. These strains acquired resistance mutations against colistin and extended spectrum β-lactamase (ESBL) and carbapenemase genes, namely ...
Prevailing models of sex-chromosome evolution were largely inspired by the stable and highly differentiated XY pairs of model organisms, such as those of mammals and flies. Recent work has uncovered an incredible diversity of sex-determining systems, bri
and a depth of coverage of at least 10x. A position was considered non-polymorphic if the dominant allele frequency was >80%. The level of strain heterogeneity of each MAG was calculated by the proportion of the total number of nonsynonymous mutations in the total number of considered ...