The main steps involved in the genomic in situ hybridization are (a) direct or indirect labeling of probe, (b) blocking DNA fragmentation, (c) preparation of slide, (d) denaturation of probe and blocking DNA in a hybridization mixture, (e) addition of the probe and the blocking DNA with ...
All patients were initially required to have central testing for triple trisomies of chromosomes 4, 10, and 17 (TT) and BCR-ABL1, ETV6-RUNX1, or KMT2A rearrangement (KMT2A-R) using fluorescence in situ hybridization. After induction, patients were classified into 1 of 3 risk groups: SR ...