The Ig domains are classified into four different types: variable (V-set), constant-1 (C1-set), constant-2 (C2-set), and intermediate (I-set) [60]. These domains form a common core Greek-key β-sandwich structure [61] and differ in the number of strands in the β-sheets as well...
These immunoglobulin domains are then subclassified as C1-set, C2-set, V-set, I-set, or Ig-like, based on their similarity to the constant, variable, or intermediate sequence patterns in immunoglobulins (“antibodies”) (Smith and Xue, 1997). Ig-cellular adhesion molecules can be arranged ...
Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches. 展开 ...
They both have the unusual codon CCT for proline at position 7, which so far has been found only in a specific set of VH genes, called the NPb family. We show that the two VH genes belong to this set. One of our BALB/c genes, VH124, is more homologous to a C57BL/6 NPb VH ...
The contribution of weakly interactions involving of C-H...π interactions, in this study we have analyzed the influence of C-H...π interactions on the structural stability of immunoglobulin proteins. In the 33 data set, a total of 128 C-H.π interactions. The most prominent representatives...
G Cryo-EM density of the pore region (C1 symmetry). H, I Views of W436/D449 and T441/Y447 for both the D1 and D3 conformations identified in the Kv1.3-nanobody structure. J Structures of the selectivity filter of the Kv1.3-nanobody complex with the D1 (left) and D3 (right) ...
Igλ low mutation was confirmed by PCR with mIglc1 VnC L/J3C1, followed by KpnI digestion. PCR was performed using AmpliTaq Gold (PerkinElmer, Waltham, MA, USA), KOD FX (TOYOBO), or AccuPrime Taq DNA polymerase (Invitrogen, Carlsbad, CA, USA). Amplified fragments were resolved by ...
The Ig-like domains are then subclassified as C1-, C2-, V-, and I-set (or -type), based on their similarity to the variable and constant regions of antibodies. Sign in to download full-size image FIG 13.3. Adhesion molecules of the immunoglobulin superfamily.(a) Ig family adhesion ...
The domains of these proteins have been grouped into four sets: variable (V-set), constant-1 (C1-set), constant-2 (C2-set) and intermediate (I-set). X-ray and NMR studies have shown that these domains form a Greek-key 尾-sandwich structure with the sets differing in the number of ...
CCIgτoM2m(C1p9μa.11re%(d2)4,I.ag7n%Td)CaIgτnDdwCCitμδh22IgM Cµ an(d19I.g2D%)C; Wδ dhiolemIagiTnsCiτn3 Pd.oomliaviancesuhso,wtheed dheigdhuecresdimaimlarinitoy awciitdh sIgeDquCeδn6ce(1o6f%I)gtThaCnτ1otshheor wdoemdahinigshest similaarnitdyIwgTitChτt4hdaot...