(seeFig. 6.3C) usually function as one of the building blocks lined up in tandem to present the ligand-binding V-set domain on the cell surface. This can be seen in manyimmune receptorssuch asCD222and CD4.23There are also many receptors that are exclusively composed of I-set domains, ...
Since a similar pattern of contacts is observed for other domains of the immunoglobulin I-set, our results are of general relevance for this protein family. Our work might also inspire a more rational approach to the investigation of domain boundaries and their influence on module stability.M. ...
上海玉博生物科技有限公司 主要致力于“VSIG4 (V-set and immunoglobulin domain-containing protein 4) VSIG4 T**细胞负调节蛋白之 yb-0479P”的生产销售。多年的“VSIG4 (V-set and immunoglobulin domain-containing protein 4) VSIG4 T**细胞负调节蛋白之 yb-0479P”
Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liv... V-set and Ig domain-containing 4 (VSIG4, CRIg, or Z39Ig), a newly identified B7-related cosignaling molecule, is a complement ...
e Topology diagram of a 7-stranded Ig domain. β-strands and β-arch loops are indicated as Si and Li, respectively, where i is the corresponding number. f Examples of de novo designed Ig backbones generated with different geometries and β-arch connections following the described rules, ...
For (i, j), Statistical significance was determined by Log-rank (Mantel-Cox) test and p-values are shown. k Gene set enrichment analysis of positive regulation of ferroptosis process genes between MM patients with hypercholesterolemia and normal MM patients in MMRF dataset. Source data are ...
IMMW IMN IMNA IMNAL IMNAS IMNATHO IMNC IMNCI IMNDA IMNERHO IMNF IMNG IMNH IMNHO IMNI IMNO IMNPO IMNQSHO IMNRC IMNS IMNSCO IMNSFHO IMNSHBCO IMNSHO ▼ Full browser ? ▲ Immunoglobulin delta-chains Immunoglobulin delta-chains Immunoglobulin delta-chains Immunoglobulin domain immunoglobulin...
Ig-like domains rarely occur in isolation but typically form concatenated chains, often with a V- or I-type domain at the N-terminus. Ig-like domains are frequently found protein domains. For example, in the human genome, there are more than 750 identified proteins with at least one Ig-...
IgE exists as a monomer, with an extra domain region in the Fc region that is important for its binding to mast cells. When antigen binds to these bound IgE molecules, the mast cells release chemical mediators, such as histamine, that contribute to the allergic response (Type I ...
The size requirement (i.e. the number of variant proteins) of a protein library of a mutated domain or a minidomain or a fusion molecule of a domain is dependent on the task. In general, a library to generate an antigen binding site de novo needs to be larger than a library used to...