set domain on the cell surface. This can be seen in manyimmune receptorssuch asCD222and CD4.23There are also many receptors that are exclusively composed of I-set domains, including immune receptor ICAM-1 (intercellular adhesion molecule-1),24neuroreceptorsNCAM,25and Dscam.26,27Thus the I-...
Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set. Structure. 1995;3:391-401.Pfuhl, M., and Pastore, A. (1995) Tertiary Structure of an Immunoglobulin- Like Domain from the Giant Muscle Protein Titin: a New Member of the...
Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liv... V-set and Ig domain-containing 4 (VSIG4, CRIg, or Z39Ig), a newly identified B7-related cosignaling molecule, is a complement ...
e Topology diagram of a 7-stranded Ig domain. β-strands and β-arch loops are indicated as Si and Li, respectively, where i is the corresponding number. f Examples of de novo designed Ig backbones generated with different geometries and β-arch connections following the described rules, ...
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In addition, an I- (or h)-type domain with an intermediate structure between the V- and C-type domains is frequently present in cell-surface receptors. Ig-like domains rarely occur in isolation but typically form concatenated chains, often with a V- or I-type domain at the N-terminus. ...
For (i, j), Statistical significance was determined by Log-rank (Mantel-Cox) test and p-values are shown. k Gene set enrichment analysis of positive regulation of ferroptosis process genes between MM patients with hypercholesterolemia and normal MM patients in MMRF dataset. Source data are ...
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ImmunoglobulinA (IgA) is quantitatively the most prevalent immunoglobulin in the body, accounting for more than 70% of total immunoglobulins, mainly involved inmucosal immunity. It is found as a dimer in tissues and secretions particularly from the gastro-intestinal and respiratory tracts, i.e. sal...
Class IgG1 κ IgG1 κ IgG1 λ IgG1 κ DARPina Single-domain antibody Affinity constant KD [M] 7 × 10−9 M 1.4 × 10−10 M 2 × 10−12 M ? 12 × 10−9 M 1.4 × 10−9 M Free IgE binding + ++ +++ − + + IgE:FcεRIα complex disruption + ? ? − +++ ...