[60]. These proteins are highly modular, consisting of several Ig domains as well as otherprotein domainswith different functions. The Ig domains are classified into four different types: variable (V-set), constant-1 (C1-set), constant-2 (C2-set), and intermediate (I-set)[60]. These ...
The domains of these proteins have been grouped into four sets: variable (V-set), constant-1 (C1-set), constant-2 (C2-set) and intermediate (I-set). X-ray and NMR studies have shown that these domains form a Greek-key 尾-sandwich structure with the sets differing in the number of ...
Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches. 展开 ...
and DE loops of a C1-set domain of an Ig or an Ig-like molecule; AB, CC′, EF, FG, BC, and EC′ loops of a C2-set domain of an Ig or an Ig-like molecule; DE, BD, GF, A(A1A2)B, and EF loops of I(Intermediate)-set domain of an Ig or Ig-like molecule. ...
A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin 魏 chain binding activity.YASUOKA Jun-...
The variant sequence of a SEQ ID NO:1-derived substituted amino acid sequence may also be set such that the other amino acid substitution(s) such as Gly29Ala remain(s) (in other words, such that the immunoglobulin-binding protein of the present invention has the other amino acid ...
The contribution of weakly interactions involving of C-H...π interactions, in this study we have analyzed the influence of C-H...π interactions on the structural stability of immunoglobulin proteins. In the 33 data set, a total of 128 C-H.π interactions. The most prominent representatives...
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In fact, another PfEMP1 protein, IT4VAR60, binds to IgM and blocks the deposition of C1q (a key component of the complement C1 complex) on the iRBCs, thereby protecting the iRBCs from complement-mediated lysis23. To examine whether VAR2CSA directly inhibits complement-dependent cytotoxicity, ...
The Ig-like domains are then subclassified as C1-, C2-, V-, and I-set (or -type), based on their similarity to the variable and constant regions of antibodies. Sign in to download full-size image FIG 13.3. Adhesion molecules of the immunoglobulin superfamily.(a) Ig family adhesion ...