The Ig domains are classified into four different types: variable (V-set), constant-1 (C1-set), constant-2 (C2-set), and intermediate (I-set) [60]. These domains form a common core Greek-key β-sandwich structure [61] and differ in the number of strands in the β-sheets as well...
The V set has an extra C″ strand in the latter β-sheet, while sets C1 and C2 lack strands A′, and A′ and D, respectively. For all of the sets, primarily hydrophobic residues form the core of the β-sheet sandwich, and there is commonly an inter-sheet disulfide bond present (...
They both have the unusual codon CCT for proline at position 7, which so far has been found only in a specific set of VH genes, called the NPb family. We show that the two VH genes belong to this set. One of our BALB/c genes, VH124, is more homologous to a C57BL/6 NPb VH ...
Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches. 展开 ...
The absent C1-C4 disulfide bond in group A SRCR domains (SCARA1, SCARA5 and MARCO) are highlighted in yellow in group B SRCR domains (AIM, CD6, CD5, SALSA). The residues at the binding interface of AIM/IgM are highlighted in orange (AIM/J interface) and grey (AIM/Fcμ interface)...
The contribution of weakly interactions involving of C-H...π interactions, in this study we have analyzed the influence of C-H...π interactions on the structural stability of immunoglobulin proteins. In the 33 data set, a total of 128 C-H.π interactions. The most prominent representatives...
In fact, another PfEMP1 protein, IT4VAR60, binds to IgM and blocks the deposition of C1q (a key component of the complement C1 complex) on the iRBCs, thereby protecting the iRBCs from complement-mediated lysis23. To examine whether VAR2CSA directly inhibits complement-dependent cytotoxicity, ...
hematopoietic cells, besides synthesis of sialyl core 1 structures, the T antigen is usually further modified by core 2 β6-N-acetylglucosaminyltransferase (C2GnT) and/or by core 1 β3-N-acetylglucosaminyltransferase (C1GnT) to form Core 2 [Galβ1,3(GlcNAcβ1,6)GalNAcα-Ser/Thr], and...
Many of the Ig carbohydrate moieties as well as the sites on the Ig molecule that bind to complement component C1 are generally located within the CH2 domain of Igs with three CH domains, and in the CH3 domain of Igs with four CH domains. In contrast to other CH domains, the CH2 (or...
The negative control was used as a blank, and ED50 values (doses causing 50% cell growth inhibition) were calculated, where the cell growth of the positive control was set at 100%. TABLE 8 Relative Specific activity (%) Conc. activity for native (ng/ml) (IU/mg) IFNα Native IFNα ...