[60]. These proteins are highly modular, consisting of several Ig domains as well as otherprotein domainswith different functions. The Ig domains are classified into four different types: variable (V-set), constant-1 (C1-set), constant-2 (C2-set), and intermediate (I-set)[60]. These ...
C1q binds to residues in the CH3 domain of IgM and the CH2 domain of IgG. Some isotypes, when interacting with antigen, can activate the alternative pathway of complement that does not use C1 but gives rise to the same biological activities. Cell binding and opsonization The Fc portion o...
33. The conditionally active binding protein of claim 29, wherein the non-CDR loop is from a variable domain, a constant domain, a C1-set domain, a C2-set domain, an I-domain, or any combinations thereof. 34. The conditionally active binding protein of claim 29, wherein the binding mo...
A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin 魏 chain binding activity.YASUOKA Jun-...
Moreover, there are two N-linked glycosylation sites (N116 and N135) in the D1 domain and one N-linked glycosylation site (N137) in the D2 domain of the chicken LILRAs (Figure 1B). The cytoplasmic domains of human and mouse LILRA2 and LILRA6 are short (13-aa) compared to ...
In fact, another PfEMP1 protein, IT4VAR60, binds to IgM and blocks the deposition of C1q (a key component of the complement C1 complex) on the iRBCs, thereby protecting the iRBCs from complement-mediated lysis23. To examine whether VAR2CSA directly inhibits complement-dependent cytotoxicity, ...
sequence of SEQ ID NO:1 except for the presence of the amino acid substitutions Lys4Arg, Lys7Glu, Asn11Lys, Glu15Ala, Asn21Tyr, Gly29Ala, and Lys58Glu) except that the amino acid sequence of the protein has at least one amino acid substitution selected from the following (C1) to (...
A ChIP assay using antibodies targeting either the N-terminus (N1) or C-terminus (C1) of GANP confirmed a preferential interaction of GANP to the q5 region of the IgVH (Fig. 4c). A ChIP assay was also used to examine the distribution of the histone H1, Spt5 and transcription pausing...
(Chapter 1): Figure 1, Evolution of the Immune System Figure 2, The Immunoglobulin Domain Figure 3, Antibody Folds Figure 4, The Antibody Figure 5, Splice Joining Sequences Figure 6, DNA and mRNA Splicing of Immunoglobulin Genes Figure 7, Species Variation in Arrangement of Immunoglobulin Genes...
hematopoietic cells, besides synthesis of sialyl core 1 structures, the T antigen is usually further modified by core 2 β6-N-acetylglucosaminyltransferase (C2GnT) and/or by core 1 β3-N-acetylglucosaminyltransferase (C1GnT) to form Core 2 [Galβ1,3(GlcNAcβ1,6)GalNAcα-Ser/Thr], and...