Astrocytes express a plethora of receptors that detect viral particles and trigger signaling cascades, leading to an innate immune response. In this review, we summarize the current knowledge on virus receptors that initiate the release of inflammatory cytokines from astrocytes and depict the in...
In the present study, we examined the role of TLR2/4 signaling on various astrocyte functions (i.e., proliferation, pro-inflammatory mediator production, regulatory mechanisms, etc) by stimulating astrocytes with potent exogenous TLR2/4 agonist, bacterial lipopolysaccharide (LPS). Newborn astrocytes...
Astrocytes up-regulate all three TLRs following TLR3 ligation. Our data indicate that activation of innate immune responses in the CNS is not homogeneous but rather tailored according to cell type and environmental signal. 展开 关键词: Signaling Responses Microglia Astrocytes ...
Grk2 is an essential regulator of CXCR7 signalling in astrocytes. Cell. Mol. Neurobiol. 33, 111–118 (2012). Article CAS PubMed Google Scholar Singh, R. K. & Lokeshwar, B. L. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. ...
Finally, one gene signature, termed D (Lipopolysaccharides, LPS), showed greatest enrichment in LPS-stimulated DCs and was composed of MHC class I family genes (HLA-B, HLA-C, HLA-G, HLA-J) and a large number of genes with direct roles in interferon signaling (IRF7, IRF9, STAT1, ISG...
Identification of novel immune molecular pathways and response markers to OmniGen-AF® supplementation in a rat modelOmniGen-AF... JA Branson - 《Attribution United States》 被引量: 0发表: 2014年 Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechan...
The neurovascular unit, composed of vascular endothelium, vascular smooth muscle, extracellular matrix components, pericytes, astrocytes, microglia, and neurons, allows the highly regulated exchange of molecules and the limited trafficking of cells to the brain through coordinated signaling activity. The pa...
Actin is not required for nanotubular protrusions of primary astrocytes grown on metal nano-lawn. Cutting edge: membrane nanotubes connect immune cells. J. Immunol. 173: 1511-1513.Gimsa, U., Iglic, A., Fiedler, S., Zwanzig, M., Kralj-Iglic,... U Gimsa,Igli, Ale,S Fiedler,... -...
Inactivation of TGF-β signaling in CAR-T cells Zaopeng Yang Yang-Xin Fu Comments & Opinion26 Feb 2024Cellular & Molecular Immunology Volume: 21, P: 309-310 What dictates tumour cell sensitivity to exercise? John P. Campbell David Walzik ...
agonists, and emphasized the prospects of targeting innate immune pathways and the importance of combination multi-targeted therapies in overcoming abnormal tumor signaling pathways. Finally, we discussed how to overcome the barriers to targeted therapy of innate immune pathways in the future. The core...