Subsequent to the summation of probe value, a total of 223 genes were identified as DEGs between the normal and glaucoma samples, including 74 downregulated and 149 upregulated genes. In addition, the DEGs were found to be associated with several functions, including response to wounding, ...
This pathway also participates in the initial stage of stroke by regulating Ca2+signaling. This pathway is also related to stem cell functions. The role played by G alpha (i) signaling in pluripotent stem cells is largely unknown, but it involves the maintenance of pluripotency and the directed...
Astrocyte-derived TGF-beta1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells. Cell Rep. 2015;11:592–604. Article CAS PubMed Google Scholar Massague J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753–91. ...
et al. Robust decomposition of cell type mixtures in spatial transcriptomics. Nat. Biotechnol. (2021).https://doi.org/10.1038/s41587-021-00830-w Li, D. et al. KRT17 Functions as a tumor promoter and regulates proliferation, migration and invasion in pancreatic cancer via mTOR/S6k1 pathway...
Activated astrocytes become hypertrophic, exhibit increased production of glial fibrillary acidic protein (GFAP), and form glial scars, which hinder axonal regeneration (Block and Hong, 2005). In the case of microglia, their normal physiological functions are not as well understood but research in ...
Every cell in an individual's body carries the same blueprint written in DNA. So scientists detect which genes are active by looking at the mRNA, which translates those instructions so that each cell can build proteins that are specific to its functions. ...
then an instructor in the Center for Systems Biology. "Our findings suggest that communication between astrocytes and microglia, via IL-3, is an important mechanism that wards off Alzheimer's disease by instructingmicrogliato adapt protective functions. With further study, IL-3 signaling may provide...
A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms’ tumor suppressor WT1 Mol. Cell. Biol., 16 (1996), pp. 6945-6956 Google Scholar Kampmann et al., 2015 M. Kampmann, M.A. Horlbeck, Y. Chen, J.C. Tsai, M.C. Bassik, L.A. Gilbert, ...
Recent advances in spatially resolved transcriptomics (SRT) technologies have enabled comprehensive characterization of gene expression patterns in the context of tissue microenvironment. To elucidate spatial gene expression variation, we present SpaGCN,
We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 alcoholics and 73 controls of European descent, and identified 129 genes that showed altered expression (FDR < 0.05) in subjects with alcohol dependence. Differentially expressed genes were enriched for pathways ...