This pathway also participates in the initial stage of stroke by regulating Ca2+signaling. This pathway is also related to stem cell functions. The role played by G alpha (i) signaling in pluripotent stem cells is largely unknown, but it involves the maintenance of pluripotency and the directed...
Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age. OBJECTIVE: Orexins have been implicated in the regulation of several physiological functions including reproduction, energy balance and vigilance state. Fo......
Describe the functions of the nervous system's main divisions, and identify the three main types of neurons. Provide examples of their functions. Describe the 3 basic functions of the nervous system, and the role that neurons play in those basic functions. Describe the functions o...
2. Systemic administration of AAVs, such as AAV93,4,5,6, allows noninvasive gene delivery, particularly in large or distributed biological structures7, but access to the brain from the periphery is restricted by the blood-brain barrier (BBB), a complex biological...
The different functions of osteoblastic and vascular niches aren’t yet known. A difference between the two niches is the oxygen level: vascular niche presents a higher oxygen level than osteoblastic niche. In this conditions, cells resume their cell cycle, undergoing mitosis[75]. Furthermore, a...
contains, in decreasing order of proportion: exci- tatory neurons, inhibitory neurons that migrated from the ventral telencephalon, radial glial, astrocytes, micro- glial, with a small subset of glia, endothelial cells, oligodendrocyte progenitor cells, and Cajal-Retzius cells [1, 40, 159]. At...
Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constraints. However,
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs a
et al. Robust decomposition of cell type mixtures in spatial transcriptomics. Nat. Biotechnol. (2021).https://doi.org/10.1038/s41587-021-00830-w Li, D. et al. KRT17 Functions as a tumor promoter and regulates proliferation, migration and invasion in pancreatic cancer via mTOR/S6k1 pathway...
Recent advances in spatially resolved transcriptomics (SRT) technologies have enabled comprehensive characterization of gene expression patterns in the context of tissue microenvironment. To elucidate spatial gene expression variation, we present SpaGCN,