We present four examples of proteins with different size and folding. We also discuss ways to distinguish among the different solutions.doi:10.1002/prot.340100104A, PastoreEuropean Molecular Biology Laboratory, Heidelberg, Federal Republic of GermanyR A, Atkinson...
G proteins of the Ras family function as molecular switches in many signalling cascades; however, little is known about where they become activated in living cells. Here we use FRET (fluorescent resonance energy transfer)-based sensors to report on the spatio-temporal images of growth-factor-induc...
In many cases of two proteins with high node2vec similarity but without direct interaction in AP–MS data, we found that neither protein had yet been tagged as bait for an affinity purification experiment. In these cases, the node2vec embedding suggests gaps in existing AP–MS data. g, ...
Part of the book series: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ((BBMCVS,volume 6)) 2507 Accesses Abstract Many visualization techniques are available to explore the cardiovascular system from usual ultrasound echography and velocimetry, multislice spiral com...
Spatial transcriptomics technologies can profile hundreds to thousands of genes at single-cell resolution, yielding a much larger number of features compared with spatial proteomics technologies such as CODEX that typically can only profile fewer than a hundred proteins. This substantial increase in the ...
Electron cryo-microscopy (Cryo-EM) technique produces 3-dimensional (3D) density images of proteins. When resolution of the images is not high enough to resolve the molecular details, it is challenging for image processing methods to enhance the molecular features. β-barrel is a particular struct...
of proteins implicated in a variety of diseases. It brings together citizen scientists who volunteer to run simulations of protein dynamics on their personal computers. Insights from this data are helping scientists to better understand biology, and providing new opportunities for developing therapeutics....
The capsid is a protective protein coat that encloses the viral genome. The shape of the capsid can vary from one type of virus to another. The capsid is made from proteins that are encoded by viral genes within their genome. The shape of the capsid serves as one basis for the classific...
Natural scenes sparsely activate neurons in the primary visual cortex (V1). However, how sparsely active neurons reliably represent complex natural images and how the information is optimally decoded from these representations have not been revealed. Usi
Multiplexed imaging enables measurement of multiple proteins in situ, offering an unprecedented opportunity to chart various cell types and states in tissues. However, cell classification, the task of identifying the type of individual cells, remains cha