A Comprehensive Survey on Knowledge Distillation of Diffusion Models Weijian Luo [9th Apr., 2023] [arXiv, 2023] [Paper]A Survey on Graph Diffusion Models: Generative AI in Science for Molecule, Protein and Material Mengchun Zhang, Maryam Qamar, Taegoo Kang, Yuna Jung, Chenshuang Zhang...
Chiral molecules come in two versions, or isomers, defined by theiroptical activity. This means that if you shine polarized light on a chiral molecule, one will rotate the light to the left (indicated by the prefix L-, or levorotatory) while the other will rotate it to the right (indicat...
S. Inhibiting HIV-1 entry: discovery of d-peptide inhibitors that target the gp41 coiled-coil pocket. Cell 99, 103–115 (1999). Article CAS PubMed Google Scholar Mandal, K. et al. Chemical synthesis and X-ray structure of a heterochiral {d-protein antagonist plus vascular endothelial ...
The future of machine learning for small-molecule drug discovery will be driven by data Article 15 October 2024 Machine learning phenomics (MLP) combining deep learning with time-lapse-microscopy for monitoring colorectal adenocarcinoma cells gene expression and drug-response Article Open access 20...
the spatial organizationof cellular structures and components. The assay is often used during drug screening to profile small molecules or other compounds on stained proteins in living cells. The pattern of cellular staining may revel morphological differences in samples treated by small molecule ...
"This structure shown here represents a high resolution, physiologically relevant hTIM-3 molecule," said author Walter Kim, MD, Ph.D., a researcher in Blumberg's laboratory and associate physician in the Department of Medicine. "Now we can understand what specific regions of the protein are ac...
A method is described for selection, alignment, and classification of molecules. The widely accepted overall trinodular structure of the protein was observed. The flexibility about the central domain of the molecule was quantitatively analyzed. A Gaussian distribution of this conformational parameter was...
Although single-molecule sensitivity has been achieved with these far-field techniques (Nie et al., 1994; Schwille et al., 1999), their spatial resolution is classically limited by diffraction, and temporal resolution is greatly sacrificed due to the scanning. A number of recent techniques have ...
Mirror Image Forms of Snow Flea Antifreeze Protein Prepared by Total Chemical Synthesis Have Identical Antifreeze Activities No experimental structure has been reported for this interesting protein molecule. Here we report the total chemical synthesis of the mirror image forms of ... BL Pentelute,Zachar...
Professor von Itzstein said the 3-D image shows the architecture and intimate atomic-level detail of a bacterial heparanase, anenzymethat degrades a sugar molecule known asheparan sulfate. He said the functionally identical human enzyme is over-expressed in cancers and is known to be associated ...